IFT74_HUMAN - dbPTM
IFT74_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IFT74_HUMAN
UniProt AC Q96LB3
Protein Name Intraflagellar transport protein 74 homolog
Gene Name IFT74
Organism Homo sapiens (Human).
Sequence Length 600
Subcellular Localization Cell projection, cilium. Cytoplasmic vesicle. Localizes along primary cilia at interphase and around the basal body/centriole at interphase and mitosis.
Protein Description Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis..
Protein Sequence MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHSTSGN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MASNHKSSAA
-----CCCCCCCCCC		37.8624719451
7Phosphorylation-MASNHKSSAARPVS
-CCCCCCCCCCCCCC		20.0528102081
8PhosphorylationMASNHKSSAARPVSR
CCCCCCCCCCCCCCC		30.6524719451
11MethylationNHKSSAARPVSRGGV
CCCCCCCCCCCCCCC		31.6981121837
14PhosphorylationSSAARPVSRGGVGLT
CCCCCCCCCCCCCCC		28.0824719451
15MethylationSAARPVSRGGVGLTG
CCCCCCCCCCCCCCC		46.2354556857
21PhosphorylationSRGGVGLTGRPPSGI
CCCCCCCCCCCCCCC		25.8028555341
26PhosphorylationGLTGRPPSGIRPLSG
CCCCCCCCCCCCCCC		49.9227966365
32PhosphorylationPSGIRPLSGNIRVAT
CCCCCCCCCCEEEEE		32.2623186163
45PhosphorylationATAMPPGTARPGSRG
EECCCCCCCCCCCCC		25.8522210691
47MethylationAMPPGTARPGSRGCP
CCCCCCCCCCCCCCC		35.63115480171
50PhosphorylationPGTARPGSRGCPIGT
CCCCCCCCCCCCCCC		28.3422210691
51MethylationGTARPGSRGCPIGTG
CCCCCCCCCCCCCCC		57.5624129315
57PhosphorylationSRGCPIGTGGVLSSQ
CCCCCCCCCCCHHHH		31.3328555341
62PhosphorylationIGTGGVLSSQIKVAH
CCCCCCHHHHEEEEC		20.1424719451
63PhosphorylationGTGGVLSSQIKVAHR
CCCCCHHHHEEEECC		31.5928857561
73PhosphorylationKVAHRPVTQQGLTGM
EEECCCCCHHCCCCC		20.1828857561
81UbiquitinationQQGLTGMKTGTKGPQ
HHCCCCCCCCCCCCC		45.1829967540
106PhosphorylationGLLRSKISELTTEVN
HHHHHHHHHHHHHHH		30.23-
122PhosphorylationLQKGIEMYNQENSVY
HHHHHHHHHCCCCEE		10.8228270605
127PhosphorylationEMYNQENSVYLSYEK
HHHHCCCCEEEEEHH		16.0428270605
129PhosphorylationYNQENSVYLSYEKRA
HHCCCCEEEEEHHHH		6.9728270605
131PhosphorylationQENSVYLSYEKRAET
CCCCEEEEEHHHHHH		17.3528270605
132PhosphorylationENSVYLSYEKRAETL
CCCEEEEEHHHHHHH		23.9128270605
203PhosphorylationAKEKQIRSVEEEIEQ
HHHHHHHHHHHHHHH		35.1924719451
215PhosphorylationIEQEKQATDDIIKNM
HHHHHHCHHHHHHHC		31.54-
234AcetylationQVKYLEMKTTNEKLL
HHHHHHCCCCCHHHH		42.7018529187
239AcetylationEMKTTNEKLLQELDT
HCCCCCHHHHHHHHH		57.4718529195
282PhosphorylationVLLHEKLYELESHRD
HHHHHHHHHHHHCHH		29.5427642862
297PhosphorylationQMIAEDKSIGSPMEE
HHHHHCCCCCCCHHH		44.4921815630
300PhosphorylationAEDKSIGSPMEEREK
HHCCCCCCCHHHHHH		21.2829255136
332AcetylationQLTDTKEKINQFIEE
HHHHHHHHHHHHHHH		48.817306307
462AcetylationKMELLESKMTEEQHS
HHHHHHHHCHHHHHH		40.2320167786
464PhosphorylationELLESKMTEEQHSLK
HHHHHHCHHHHHHHH		39.8625690035
469PhosphorylationKMTEEQHSLKSKIKQ
HCHHHHHHHHHHHHH		36.8723879269
472PhosphorylationEEQHSLKSKIKQMTT
HHHHHHHHHHHHHHH		44.9323879269
479PhosphorylationSKIKQMTTDLEIYND
HHHHHHHHCHHHHHC		32.9923879269
484PhosphorylationMTTDLEIYNDLPALK
HHHCHHHHHCCHHHH		8.0227642862
526PhosphorylationMEKQNIEYEALKTQL
HHHCCCCHHHHHHHH		11.6027642862
572PhosphorylationTKSQESDYQPIKKNV
HCCCCCCCCCCHHHH		26.0121945579
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IFT74_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IFT74_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IFT74_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBX10_HUMANUBXN10physical
26389662
TERA_HUMANVCPphysical
26389662
UFD1_HUMANUFD1Lphysical
26389662
NPL4_HUMANNPLOC4physical
26389662
SIGL7_HUMANSIGLEC7physical
28514442
TSYL4_HUMANTSPYL4physical
28514442
SKAP_HUMANKNSTRNphysical
28514442
IFT22_HUMANIFT22physical
28514442
IFT46_HUMANIFT46physical
28514442
IFT52_HUMANIFT52physical
28514442
LRRF1_HUMANLRRFIP1physical
28514442
CREB1_HUMANCREB1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IFT74_HUMAN

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Related Literatures of Post-Translational Modification

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