IFT52_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFT52_HUMAN
• UniProt AC: Q9Y366
• Protein Name: Intraflagellar transport protein 52 homolog
• Gene Name: IFT52
• Organism: Homo sapiens (Human).
• Sequence Length: 437
• Subcellular Localization: Cell projection, cilium .
• Protein Description: Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. [PubMed: 27466190 Required for the anterograde transport of IFT88]
• Protein Sequence: MEKELRSTILFNAYKKEIFTTNNGYKSMQKKLRSNWKIQSLKDEITSEKLNGVKLWITAGPREKFTAAEFEILKKYLDTGGDVFVMLGEGGESRFDTNINFLLEEYGIMVNNDAVVRNVYHKYFHPKEALVSSGVLNREISRAAGKAVPGIIDEESSGNNAQALTFVYPFGATLSVMKPAVAVLSTGSVCFPLNRPILAFYHSKNQGGKLAVLGSCHMFSDQYLDKEENSKIMDVVFQWLTTGDIHLNQIDAEDPEISDYMMLPYTATLSKRNRECLQESDEIPRDFTTLFDLSIFQLDTTSFHSVIEAHEQLNVKHEPLQLIQPQFETPLPTLQPAVFPPSFRELPPPPLELFDLDETFSSEKARLAQITNKCTEEDLEFYVRKCGDILGVTSKLPKDQQDAKHILEHVFFQVVEFKKLNQEHDIDTSETAFQNNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Ubiquitination	-----MEKELRSTIL -----CCHHHHHHHH	61.83	-
20	Phosphorylation	AYKKEIFTTNNGYKS HHHCEEEECCCHHHH	33.99	23403867
21	Phosphorylation	YKKEIFTTNNGYKSM HHCEEEECCCHHHHH	18.88	23403867
25	Phosphorylation	IFTTNNGYKSMQKKL EEECCCHHHHHHHHH	11.30	23403867
27	Phosphorylation	TTNNGYKSMQKKLRS ECCCHHHHHHHHHHC	20.26	23403867
37	Ubiquitination	KKLRSNWKIQSLKDE HHHHCCCCCCHHHHH	34.81	22817900
42	Ubiquitination	NWKIQSLKDEITSEK CCCCCHHHHHHHHHH	59.57	22817900
49	Ubiquitination	KDEITSEKLNGVKLW HHHHHHHHHCCEEEE	47.20	-
64	Ubiquitination	ITAGPREKFTAAEFE EEECCHHHCCHHHHH	49.66	-
66	Phosphorylation	AGPREKFTAAEFEIL ECCHHHCCHHHHHHH	35.71	23532336
93	Phosphorylation	MLGEGGESRFDTNIN EECCCCCCCCHHCHH	41.33	-
122	Ubiquitination	VVRNVYHKYFHPKEA HHHHHHHHHCCHHHH	31.74	-
123	Phosphorylation	VRNVYHKYFHPKEAL HHHHHHHHCCHHHHH	8.20	22210691
127	Ubiquitination	YHKYFHPKEALVSSG HHHHCCHHHHHHHCC	47.23	29967540
132	Phosphorylation	HPKEALVSSGVLNRE CHHHHHHHCCCCCHH	23.40	22210691
133	Phosphorylation	PKEALVSSGVLNREI HHHHHHHCCCCCHHH	25.99	22210691
209	Ubiquitination	HSKNQGGKLAVLGSC ECCCCCCCEEEEEEC	39.85	29967540
226	Ubiquitination	FSDQYLDKEENSKIM CCHHHCCHHHHCCHH	65.42	-
241	Phosphorylation	DVVFQWLTTGDIHLN HHHHHHHHHCCCCCC	26.27	-
364	Ubiquitination	DETFSSEKARLAQIT CCCCCCHHHHHHHHH	40.53	29967540
373	Ubiquitination	RLAQITNKCTEEDLE HHHHHHCCCCHHHHH	33.61	29967540
385	Ubiquitination	DLEFYVRKCGDILGV HHHHHHHHHHHHHCC	32.31	29967540
428	Phosphorylation	NQEHDIDTSETAFQN CCCCCCCHHHHHHHH	28.88	27732954
429	Phosphorylation	QEHDIDTSETAFQNN CCCCCCHHHHHHHHC	29.24	29214152
431	Phosphorylation	HDIDTSETAFQNNF- CCCCHHHHHHHHCC-	32.32	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFT52_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFT52_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFT52_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBX10_HUMAN	UBXN10	physical	26389662
IFT46_HUMAN	IFT46	physical	27173435
IFT74_HUMAN	IFT74	physical	27173435
IF172_HUMAN	IFT172	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.