GBB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBB1_HUMAN
• UniProt AC: P62873
• Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
• Gene Name: GNB1 {ECO:0000312|HGNC:HGNC:4396}
• Organism: Homo sapiens (Human).
• Sequence Length: 340
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction..
• Protein Sequence: MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Sulfoxidation	-------MSELDQLR -------CCHHHHHH	6.74	30846556
2	Phosphorylation	------MSELDQLRQ ------CCHHHHHHH	47.03	25159151
2	Acetylation	------MSELDQLRQ ------CCHHHHHHH	47.03	19413330
15	Ubiquitination	RQEAEQLKNQIRDAR HHHHHHHHHHHHHHH	46.64	-
15	Acetylation	RQEAEQLKNQIRDAR HHHHHHHHHHHHHHH	46.64	26822725
15	Malonylation	RQEAEQLKNQIRDAR HHHHHHHHHHHHHHH	46.64	26320211
19	Methylation	EQLKNQIRDARKACA HHHHHHHHHHHHHHH	23.05	-
22	Methylation	KNQIRDARKACADAT HHHHHHHHHHHHHCH	31.24	-
23	Ubiquitination	NQIRDARKACADATL HHHHHHHHHHHHCHH	49.92	-
23	Malonylation	NQIRDARKACADATL HHHHHHHHHHHHCHH	49.92	26320211
29	Phosphorylation	RKACADATLSQITNN HHHHHHCHHHHHHHC	27.73	25850435
31	Phosphorylation	ACADATLSQITNNID HHHHCHHHHHHHCCC	18.38	25850435
34	Phosphorylation	DATLSQITNNIDPVG HCHHHHHHHCCCCCC	17.99	23312004
50	Phosphorylation	IQMRTRRTLRGHLAK HHHHCHHHHHHHHHH	19.95	24719451
57	Ubiquitination	TLRGHLAKIYAMHWG HHHHHHHHHHHHHCC	42.48	21890473
57	Ubiquitination	TLRGHLAKIYAMHWG HHHHHHHHHHHHHCC	42.48	21890473
57	Acetylation	TLRGHLAKIYAMHWG HHHHHHHHHHHHHCC	42.48	25825284
59	Phosphorylation	RGHLAKIYAMHWGTD HHHHHHHHHHHCCCC	9.36	29496907
67	Phosphorylation	AMHWGTDSRLLVSAS HHHCCCCCEEEEEEC	25.35	24719451
72	Phosphorylation	TDSRLLVSASQDGKL CCCEEEEEECCCCCE	23.36	-
74	Phosphorylation	SRLLVSASQDGKLII CEEEEEECCCCCEEE	22.69	21712546
78	Acetylation	VSASQDGKLIIWDSY EEECCCCCEEEEECC	44.81	30588963
84	Phosphorylation	GKLIIWDSYTTNKVH CCEEEEECCCCCEEE	14.91	28152594
85	Phosphorylation	KLIIWDSYTTNKVHA CEEEEECCCCCEEEE	18.34	28152594
86	Phosphorylation	LIIWDSYTTNKVHAI EEEEECCCCCEEEEE	28.04	28152594
87	Phosphorylation	IIWDSYTTNKVHAIP EEEECCCCCEEEEEE	25.47	28152594
89	Ubiquitination	WDSYTTNKVHAIPLR EECCCCCEEEEEECC	33.05	21890473
89	Ubiquitination	WDSYTTNKVHAIPLR EECCCCCEEEEEECC	33.05	21906983
111	Phosphorylation	AYAPSGNYVACGGLD EECCCCCEEEECCHH	7.92	-
136	Phosphorylation	REGNVRVSRELAGHT CCCCEEECHHHCCCC	14.96	27794612
143	Phosphorylation	SRELAGHTGYLSCCR CHHHCCCCCEEEEEE	26.97	28152594
145	Phosphorylation	ELAGHTGYLSCCRFL HHCCCCCEEEEEEEE	9.15	28152594
147	Phosphorylation	AGHTGYLSCCRFLDD CCCCCEEEEEEEECC	11.59	28152594
159	O-linked_Glycosylation	LDDNQIVTSSGDTTC ECCCCEEECCCCCEE	20.85	29351928
160	O-linked_Glycosylation	DDNQIVTSSGDTTCA CCCCEEECCCCCEEE	22.79	29351928
201	Phosphorylation	PDTRLFVSGACDASA CCCEEEEECCCCCCH	17.22	20068231
207	Phosphorylation	VSGACDASAKLWDVR EECCCCCCHHHHHHH	16.82	20068231
209	Ubiquitination	GACDASAKLWDVREG CCCCCCHHHHHHHCC	47.84	-
209	Acetylation	GACDASAKLWDVREG CCCCCCHHHHHHHCC	47.84	25953088
266	Phosphorylation	QELMTYSHDNIICGI CCCEEECCCCEEEEE	23.02	-
277	Phosphorylation	ICGITSVSFSKSGRL EEEEEEEEECCCCCE	24.46	24719451
280	Ubiquitination	ITSVSFSKSGRLLLA EEEEEECCCCCEEEE	55.72	21890473
301	Acetylation	CNVWDALKADRAGVL CCHHHHHHHHCCCEE	50.38	26051181
301	Ubiquitination	CNVWDALKADRAGVL CCHHHHHHHHCCCEE	50.38	21906983
329	Phosphorylation	DDGMAVATGSWDSFL CCCEEEEECCHHHHH	25.75	28348404
331	Phosphorylation	GMAVATGSWDSFLKI CEEEEECCHHHHHHH	24.29	24719451
334	Phosphorylation	VATGSWDSFLKIWN- EEECCHHHHHHHCC-	26.64	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBB1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
266	H	Phosphorylation	Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GBG10_HUMAN	GNG10	physical	7665596
GBG4_HUMAN	GNG4	physical	7665596
GBG11_HUMAN	GNG11	physical	7665596
WDR26_HUMAN	WDR26	physical	22065575
RAP1A_HUMAN	RAP1A	physical	20048162
RADIL_HUMAN	RADIL	physical	20048162
PAK1_HUMAN	PAK1	physical	12887923
RASD1_HUMAN	RASD1	physical	16225846
PHLP_HUMAN	PDCL	physical	19376773
GBG2_HUMAN	GNG2	physical	19376773
GBG2_HUMAN	GNG2	physical	15782186
GNAS3_HUMAN	GNAS	physical	15782186
GNAS2_HUMAN	GNAS	physical	15782186
ALEX_HUMAN	GNAS	physical	15782186
GNAS1_HUMAN	GNAS	physical	15782186
ARRB1_HUMAN	ARRB1	physical	18729826
GNAI1_HUMAN	GNAI1	physical	16371464
GNAI2_HUMAN	GNAI2	physical	16371464
GNAI3_HUMAN	GNAI3	physical	16371464
GNA11_HUMAN	GNA11	physical	22939629
GNAI1_HUMAN	GNAI1	physical	22939629
GNAI2_HUMAN	GNAI2	physical	22939629
GNAI3_HUMAN	GNAI3	physical	22939629
NOL11_HUMAN	NOL11	physical	21988832
GBG1_HUMAN	GNGT1	physical	12782285
GBG2_HUMAN	GNG2	physical	12782285
GBG3_HUMAN	GNG3	physical	12782285
GBG4_HUMAN	GNG4	physical	12782285
GBG5_HUMAN	GNG5	physical	12782285
GBG7_HUMAN	GNG7	physical	12782285
GBG8_HUMAN	GNG8	physical	12782285
GBG10_HUMAN	GNG10	physical	12782285
GBG11_HUMAN	GNG11	physical	12782285
GBG12_HUMAN	GNG12	physical	12782285
GBG13_HUMAN	GNG13	physical	12782285
GBG2_HUMAN	GNG2	physical	12606627
MTOR_HUMAN	MTOR	physical	24462769
RICTR_HUMAN	RICTOR	physical	24462769
RPTOR_HUMAN	RPTOR	physical	24462769
COX41_HUMAN	COX4I1	physical	26344197
GNA11_HUMAN	GNA11	physical	26344197
GNAQ_HUMAN	GNAQ	physical	26344197
RACK1_HUMAN	GNB2L1	physical	19917775
FYN_HUMAN	FYN	physical	19917775
FAK1_HUMAN	PTK2	physical	19917775
TCPA_DROME	T-cp1	physical	25675501
TCPG_DROME	Cctgamma	physical	25675501
P85A_HUMAN	PIK3R1	physical	19117013
PK3CA_HUMAN	PIK3CA	physical	19117013
AKT1_HUMAN	AKT1	physical	19117013
ARBK1_HUMAN	ADRBK1	physical	15102938

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.