TCPG_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCPG_DROME
• UniProt AC: P48605
• Protein Name: T-complex protein 1 subunit gamma
• Gene Name: CCT3 {ECO:0000312|FlyBase:FBgn0015019}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 544
• Subcellular Localization: Cytoplasm.
• Protein Description: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin..
• Protein Sequence: MFGGQQPILVLSQNTKRESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILREITVQHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREALEDIVGHLQSQLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEVDIKRYAKVEKIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGEQDFTRMLQIEEEFVQRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNLRIARACGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDILNETERNLQDALHVARNLVLEPRLVAGGGAVEMAASQLLTRKQVKGPYTAVAHALEIIPRTLAQNCGANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVETAILLLRIDDIVSGSKKRGGNEPTNPAAMAQGQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
198	Acetylation	GRLEVDIKRYAKVEK CCEEEEEEEEEEEEE	34.59	21791702
224	Acetylation	LKGVMINKDVTHPKM EEEEEECCCCCCHHH	42.52	21791702
254	Phosphorylation	LEYKKGESQTNVEII CEECCCCCCCCEEEE	51.47	25749252
308	Acetylation	LAQHYLLKAGITAIR HHHHHHHHHHHHHHH	41.81	21791702
355	Acetylation	GAGLFEVKKIGDEYF CCEEEEEEEECCCEE	31.32	21791702
382	Phosphorylation	TILLRGASKDILNET EEEECCCCHHHHHHH	33.41	22817900
455	Phosphorylation	AQNCGANTIRALTAL HHHCCHHHHHHHHHH	16.00	21082442
483	Phosphorylation	AWGIDGESGEIVDMN EEEECCCCCEEEECE	47.45	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCPG_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCPG_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCPG_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IDH3A_DROME	l(1)G0156	physical	22036573
CCD1P_DROME	Cyp12d1-p	physical	22036573
NFS1_DROME	CG12264	physical	22036573
2AAA_DROME	Pp2A-29B	physical	22036573
ACADM_DROME	CG12262	physical	22036573
PRS8_DROME	Rpt6	physical	22036573
ARL8_DROME	Gie	physical	22036573
KRH2_DROME	Kr-h2	physical	22036573
ATPG_DROME	ATPsyn-gamma	physical	22036573
TERA_DROME	TER94	physical	22036573
RS10B_DROME	RpS10b	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.