dbPTM

TERA_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TERA_DROME
UniProt AC	Q7KN62
Protein Name	Transitional endoplasmic reticulum ATPase TER94
Gene Name	TER94
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	801
Subcellular Localization	Cytoplasm . Nucleus . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (PubMed:18590813).
Protein Description	Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in the ubiquitin-proteasome system. Important for oskar mRNA localization and/or anchoring during oogenesis. Involved in germ cell formation..
Protein Sequence	MADSKGEDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQAKMDELQLFRGDTVILKGKRRKETVCIVLSDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDVKYGKRVRILPIDESTEGVTGNLFEIYLKPYFLEAYRPIHMGDNFIVRAAMRPIEFKVVLTDPEPYCIVAPETVIFCDGDPIKREEEEESLNAVGYDDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVERRIVSQLLTLMDGMKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVLRIHTKNMKLHDDVDLEQIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAMTKSSPSALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGNVGDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSREAILKANLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAENQNSAMDMDEDDPVPEITSAHFEEAMKFARRSVSDNDIRKYEMFAQTLQQSRGFGQNFRFPGQTGNTSGSGNNLPVNSPGDNGDDDLYS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MADSKGEDLAT ----CCCCCCHHHHH	32.78	19429919
5	Acetylation	---MADSKGEDLATA ---CCCCCCHHHHHH	67.86	21791702
15	Acetylation	DLATAILKRKDRPNR HHHHHHHHCCCCCCC	51.82	21791702
716	Phosphorylation	ERAENQNSAMDMDED HHHHHHCCCCCCCCC	18.40	10656772
744	Phosphorylation	AMKFARRSVSDNDIR HHHHHHHCCCHHHHH	22.03	19429919
746	Phosphorylation	KFARRSVSDNDIRKY HHHHHCCCHHHHHHH	31.76	19429919
782	Phosphorylation	QTGNTSGSGNNLPVN CCCCCCCCCCCCCCC	37.81	21082442
790	Phosphorylation	GNNLPVNSPGDNGDD CCCCCCCCCCCCCCC	30.41	19429919
800	Phosphorylation	DNGDDDLYS------ CCCCCCCCC------	21.23	19429919
801	Phosphorylation	NGDDDLYS------- CCCCCCCC-------	40.83	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TERA_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TERA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TERA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP6A_DROME	Hsp67Ba	physical	14605208
MFN1_HUMAN	MFN1	physical	23498974
MFN2_HUMAN	MFN2	physical	23498974
MARF_DROME	Marf	physical	23498974
RS27A_DROME	RpS27A	physical	24292889
DERL1_DROME	Der-1	genetic	25255315
RB27C_DROME	Hrb27C	genetic	20519548
DIAP1_DROME	th	genetic	21343367
PTPM1_DROME	Plip	genetic	21304887
HRD1_DROME	sip3	genetic	25255315
RS10B_DROME	RpS10b	physical	22036573
DERL1_DROME	Der-1	physical	25255315
TERA_DROME	TER94	physical	23498974
CLU_DROME	clu	physical	26931463

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TERA_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells."; Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.; Mol. Biosyst. 3:275-286(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-716, AND MASSSPECTROMETRY.	17372656 [Abstract]