MARF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MARF_DROME
• UniProt AC: Q7YU24
• Protein Name: Transmembrane GTPase Marf
• Gene Name: Marf
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 810
• Subcellular Localization: Mitochondrion outer membrane; Multi-pass membrane protein.
• Protein Description: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission (By similarity)..
• Protein Sequence: MAAYLNRTISMVTGQTGPADDDRHASSTDTVDKSGPGSPLSRFNSSLQQSGSTMAANLLPESRLYQSNDKSPLQIFVRAKKKINDIYGEIEEYVHETTTFINALHAEAEIVDKAERELFESYVYKVAAIREVLQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGEAYLMTEGSEEKLNVVNIKQLANALCQEKLCESSLVRIFWPRERCSLLRDDVVFVDSPGVDVSANLDDWIDNHCLNADVFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWDASANEPECQESVKSQHTERCIDFLTKELKVSNEKEAAERVFFVSARETLQARIEEAKGNPPHMGAIAEGFQIRYFEFQDFERKFEECISQSAVKTKFQQHSSRGKSVSGDMKSMLDNIYERITIFRNLKQDQKNLLTERIQGTETQMMQVTREMKMKIHNMVEEVEEKVSKALNEEIWRLGVLIDEFNMPFHPERLVLNIYKKELNAHVESGLGSNLRARLSMALAMNVESAQTEMTDRMHALVPNEQLLATSTKMVVRTQPFEMLYSLNCQNLCADFQEDLEFKFSWGIAAMIQRFTGKVRERSKKGQPALVNRQSSIGHSVSTPTTTPVEATPVCLLPAPVVAGITPEQLSLISRFAVSSIGSQGTVGGLVVAGVMLKTIGWRVLVGVGALYGCIYLYERLSWTNSAKERTFKSQYVRHATKKLKMIVDLTSANCSHQVQQELSSTFARLCRTVDTATTDMNDELKTLDSQLNILEANQKQLKLLRNKANYIQNELDIFEHNYISPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAAYLNRTISMVTGQ CCHHHCCEEEHHCCC	19.14	19429919
10	Phosphorylation	AYLNRTISMVTGQTG HHHCCEEEHHCCCCC	13.44	19429919
34	Phosphorylation	STDTVDKSGPGSPLS CCCCCCCCCCCCCHH	45.84	29892262
38	Phosphorylation	VDKSGPGSPLSRFNS CCCCCCCCCHHHHHH	26.29	19429919
41	Phosphorylation	SGPGSPLSRFNSSLQ CCCCCCHHHHHHHHH	37.90	19429919
70	Ubiquitination	RLYQSNDKSPLQIFV HHCCCCCCCCHHHHH	59.22	31113955
553	Phosphorylation	PNEQLLATSTKMVVR CHHHHCCCCCEEEEE	36.58	18327897
554	Phosphorylation	NEQLLATSTKMVVRT HHHHCCCCCEEEEEC	22.03	22817900
555	Phosphorylation	EQLLATSTKMVVRTQ HHHCCCCCEEEEECC	20.85	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MARF_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MARF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MARF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBIQP_DROME	Ubi-p63E	physical	20194754
SODC_DROME	Sod	genetic	21148429
UBIQP_DROME	Ubi-p63E	physical	20383334

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-8; SER-38; THR-553;SER-554 AND THR-555, AND MASS SPECTROMETRY.
PubMed: 18327897