SODC_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SODC_DROME
• UniProt AC: P61851
• Protein Name: Superoxide dismutase [Cu-Zn] {ECO:0000303|PubMed:3110743}
• Gene Name: Sod1 {ECO:0000312|FlyBase:FBgn0003462}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 153
• Subcellular Localization: Cytoplasm.
• Protein Description: Destroys radicals which are normally produced within the cells and which are toxic to biological systems..
• Protein Sequence: MVVKAVCVINGDAKGTVFFEQESSGTPVKVSGEVCGLAKGLHGFHVHEFGDNTNGCMSSGPHFNPYGKEHGAPVDENRHLGDLGNIEATGDCPTKVNITDSKITLFGADSIIGRTVVVHADADDLGQGGHELSKSTGNAGARIGCGVIGIAKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	TVFFEQESSGTPVKV EEEEEECCCCCEEEE	33.49	22668510
24	Phosphorylation	VFFEQESSGTPVKVS EEEEECCCCCEEEEE	46.03	22668510
26	Phosphorylation	FEQESSGTPVKVSGE EEECCCCCEEEEEEE	27.19	22668510
53	Phosphorylation	VHEFGDNTNGCMSSG EEEECCCCCCCCCCC	37.41	17372656
59	Phosphorylation	NTNGCMSSGPHFNPY CCCCCCCCCCCCCCC	29.47	17372656
104	Phosphorylation	NITDSKITLFGADSI ECCCCCEEEEECCCC	21.55	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SODC_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SODC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SODC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TREA_DROME	Treh	physical	22036573
FKB12_DROME	FK506-bp2	physical	22036573
THIO2_DROME	Trx-2	physical	22036573
SH3BG_DROME	Sh3beta	physical	22036573
TNG2_DROME	Tango2	physical	22036573
NLP_DROME	Nlp	physical	22036573
CALR_DROME	Crc	physical	22036573
ORN_DROME	CG10214	physical	22036573
PDI_DROME	Pdi	physical	22036573
PPIA_DROME	Cyp1	physical	22036573
TRXR1_DROME	Trxr-1	physical	22036573
SSBP_DROME	mtSSB	physical	22036573
NIF3L_DROME	CG4278	physical	22036573
RS21_DROME	RpS21	physical	22036573
TAF5_DROME	Taf5	physical	22036573
WWOX_DROME	Wwox	genetic	21075834
SODM_DROME	Sod2	genetic	24656823
SODC_DROME	Sod	physical	7567977

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-53 AND SER-59, AND MASSSPECTROMETRY.
PubMed: 17372656