SH3BG_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SH3BG_DROME
• UniProt AC: Q9NFP5
• Protein Name: SH3 domain-binding glutamic acid-rich protein homolog
• Gene Name: Sh3beta
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 158
• Protein Sequence: MVLKVYVSGMSGNKEVKKRQQRVLMILDSKNIKYDTVDITEPGKESEKELMQNKSTSNGGTVSDPEPRHPLPPQLFNDDEYCGDYDAFDMANEIDTLEVFLKLAPADTTAVSTAQIELKQENGDAKKEEAETEAEDKKTEAGDGDVDVKEEAAEKAEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	KVYVSGMSGNKEVKK EEEEECCCCCHHHHH	42.62	22817900
30	Acetylation	VLMILDSKNIKYDTV EEEEEECCCCCEEEC	63.46	21791702
33	Acetylation	ILDSKNIKYDTVDIT EEECCCCCEEECCCC	46.60	21791702
48	Acetylation	EPGKESEKELMQNKS CCCCHHHHHHHHCCC	66.48	21791702
109	Phosphorylation	KLAPADTTAVSTAQI HHCCCCCCCEEEEEE	26.13	17372656
132	Phosphorylation	AKKEEAETEAEDKKT HHHHHHHHHHHHHHC	47.76	19429919
139	Phosphorylation	TEAEDKKTEAGDGDV HHHHHHHCCCCCCCC	36.49	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SH3BG_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SH3BG_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SH3BG_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THIO2_DROME	Trx-2	physical	22036573
NACA_DROME	Nacalpha	physical	22036573
YC17_DROME	CG16817	physical	22036573
PSA1_DROME	Prosalpha6	physical	22036573
TCTP_DROME	Tctp	physical	22036573
PGK_DROME	Pgk	physical	22036573
TERA_DROME	TER94	physical	22036573
Y9705_DROME	CG9705	physical	22036573
JUPIT_DROME	Jupiter	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-109, AND MASSSPECTROMETRY.
PubMed: 17372656