PSA1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSA1_DROME
• UniProt AC: P12881
• Protein Name: Proteasome subunit alpha type-1
• Gene Name: Prosalpha6
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 279
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity..
• Protein Sequence: MFRNQYDSDVTVWSPQGRLHQVEYAMEAVKLGTATVGLKNKDYAVLVALCKPTSELSDTQRKIIPIDDHLGISIAGLTADARVLSRYLRSECLNYKHSYDTTYPVSRLITNLGNKMQTTTQRYDRRPYGVGLLVAGYDERGPHIYQVTPSATFFNCKANSIGSRSQSARTYLEKNLNKFLDSSKDEIIRHGIRAILGTLPTDEQGKDAGQYDITVAIVGKDQPFTILSNKDSAKHVAIAKENDNDTPRNDDDDDRPSPPEEPAAGPRDPEVLVATEQRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	DSDVTVWSPQGRLHQ CCCCEEECCCCCCHH	11.74	30478224
103	Phosphorylation	KHSYDTTYPVSRLIT CCCCCCCCCHHHHHH	12.06	-
174	Acetylation	SARTYLEKNLNKFLD HHHHHHHHHHHHHHH	65.23	21791702
178	Acetylation	YLEKNLNKFLDSSKD HHHHHHHHHHHCCHH	50.93	21791702
184	Acetylation	NKFLDSSKDEIIRHG HHHHHCCHHHHHHHH	64.43	21791702
246	Phosphorylation	AKENDNDTPRNDDDD EEECCCCCCCCCCCC	30.33	22668510
257	Phosphorylation	DDDDDRPSPPEEPAA CCCCCCCCCCCCCCC	54.72	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSA1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSA1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSA1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSA4_DROME	Prosalpha3	physical	22036573
TERA_DROME	TER94	physical	22036573
PSMF1_DROME	PI31	physical	23622245

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.