JUPIT_DROME - dbPTM
JUPIT_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID JUPIT_DROME
UniProt AC Q9I7K0
Protein Name Microtubule-associated protein Jupiter {ECO:0000303|PubMed:16518797}
Gene Name Jupiter {ECO:0000312|EMBL:AAG22143.2}
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 208
Subcellular Localization Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle .
Protein Description Binds to all microtubule populations..
Protein Sequence MAAYAAFKHVELYNVGKAKKRVLRPPGGGSSDIFGSEMPQTPRNVKNRMASNIFAAEKDNGVKNNVRQGAHRFYFIGDAPRRGQKTVDSHSRLFGEPTRPITPGKNHMKSSIPFGQNTEAVAAQKLLTTNGHYNGKSGSVSSASSSVSSSTENLKMNSGSRSEGNPVTGEGYKVVANEYSQRQESSNGGTPVINKNRIPPGGYSSGLW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24 (in isoform 6)Phosphorylation-32.2918511481
24 (in isoform 5)Phosphorylation-32.2918511481
24 (in isoform 2)Phosphorylation-32.2918511481
30PhosphorylationLRPPGGGSSDIFGSE
ECCCCCCCCCCCCCC		28.2822817900
31PhosphorylationRPPGGGSSDIFGSEM
CCCCCCCCCCCCCCC		37.6921082442
35 (in isoform 6)Phosphorylation-24.0318511481
35 (in isoform 5)Phosphorylation-24.0318511481
35 (in isoform 2)Phosphorylation-24.0318511481
41PhosphorylationFGSEMPQTPRNVKNR
CCCCCCCCCCCHHHH		20.5325749252
51PhosphorylationNVKNRMASNIFAAEK
CHHHHHHHHEEEEHH		22.5521082442
58AcetylationSNIFAAEKDNGVKNN
HHEEEEHHHCCCCCC		52.3321791702
91PhosphorylationQKTVDSHSRLFGEPT
CCCCCCCCHHCCCCC		34.3322817900
98PhosphorylationSRLFGEPTRPITPGK
CHHCCCCCCCCCCCC		44.7925749252
102PhosphorylationGEPTRPITPGKNHMK
CCCCCCCCCCCCCCC		28.7719429919
110PhosphorylationPGKNHMKSSIPFGQN
CCCCCCCCCCCCCCC		26.4019429919
111PhosphorylationGKNHMKSSIPFGQNT
CCCCCCCCCCCCCCH		28.8519429919
131 (in isoform 2)Phosphorylation-23.6727794539
132 (in isoform 2)Phosphorylation-18.2427794539
133 (in isoform 2)Phosphorylation-27.3227794539
134 (in isoform 2)Phosphorylation-45.8227794539
137PhosphorylationNGHYNGKSGSVSSAS
CCCCCCCCCCCCCCC		37.3821082442
139PhosphorylationHYNGKSGSVSSASSS
CCCCCCCCCCCCCCC		26.3919060867
141PhosphorylationNGKSGSVSSASSSVS
CCCCCCCCCCCCCCC		23.1429892262
142PhosphorylationGKSGSVSSASSSVSS
CCCCCCCCCCCCCCC		29.9830478224
144PhosphorylationSGSVSSASSSVSSST
CCCCCCCCCCCCCCC		25.7029892262
145PhosphorylationGSVSSASSSVSSSTE
CCCCCCCCCCCCCCC		34.1819060867
146PhosphorylationSVSSASSSVSSSTEN
CCCCCCCCCCCCCCC		24.4319060867
148PhosphorylationSSASSSVSSSTENLK
CCCCCCCCCCCCCCC		22.1023607784
149PhosphorylationSASSSVSSSTENLKM
CCCCCCCCCCCCCCC		38.8425749252
150PhosphorylationASSSVSSSTENLKMN
CCCCCCCCCCCCCCC		32.0310731132
151PhosphorylationSSSVSSSTENLKMNS
CCCCCCCCCCCCCCC		30.7323607784
158PhosphorylationTENLKMNSGSRSEGN
CCCCCCCCCCCCCCC		34.3522817900
160PhosphorylationNLKMNSGSRSEGNPV
CCCCCCCCCCCCCCC		32.2422817900
162PhosphorylationKMNSGSRSEGNPVTG
CCCCCCCCCCCCCCC		52.1019429919
172PhosphorylationNPVTGEGYKVVANEY
CCCCCCCEEEEECCC		9.0519429919
180PhosphorylationKVVANEYSQRQESSN
EEEECCCCCCHHHCC		16.8321082442
185PhosphorylationEYSQRQESSNGGTPV
CCCCCHHHCCCCCCC		22.2919429919
186PhosphorylationYSQRQESSNGGTPVI
CCCCHHHCCCCCCCC		38.4519429919
190PhosphorylationQESSNGGTPVINKNR
HHHCCCCCCCCCCCC		18.7719429919
203PhosphorylationNRIPPGGYSSGLW--
CCCCCCCCCCCCC--		12.9418281928
204PhosphorylationRIPPGGYSSGLW---
CCCCCCCCCCCC---		22.6221082442
205PhosphorylationIPPGGYSSGLW----
CCCCCCCCCCC----		29.4421082442
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of JUPIT_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of JUPIT_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of JUPIT_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CADF_DROMEtsrphysical
14605208
DEI_DROMEtxphysical
14605208
SAP18_DROMEBin1physical
14605208
DORS_DROMEdlphysical
14605208
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of JUPIT_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-98; THR-102; SER-139 ANDSER-150, AND MASS SPECTROMETRY.
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; THR-41; THR-102;SER-111 AND SER-150, AND MASS SPECTROMETRY.

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