CADF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CADF_DROME
• UniProt AC: P45594
• Protein Name: Cofilin/actin-depolymerizing factor homolog
• Gene Name: tsr {ECO:0000303|PubMed:8522587, ECO:0000312|FlyBase:FBgn0011726}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 148
• Subcellular Localization: Cytoplasm, cytoskeleton. Nucleus matrix.
• Protein Description: Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics. [PubMed: 21205790 Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation]
• Protein Sequence: MASGVTVSDVCKTTYEEIKKDKKHRYVIFYIRDEKQIDVETVADRNAEYDQFLEDIQKCGPGECRYGLFDFEYMHQCQGTSESSKKQKLFLMSWCPDTAKVKKKMLYSSSFDALKKSLVGVQKYIQATDLSEASREAVEEKLRATDRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASGVTVSDV -----CCCCCCHHHH	32.28	19429919
19	Acetylation	KTTYEEIKKDKKHRY HHCHHHHHCCCCCCE	59.19	21791702
35	Acetylation	IFYIRDEKQIDVETV EEEECCCCCCCCEEH	57.76	21791702
80	Phosphorylation	YMHQCQGTSESSKKQ HHEECCCCCCCHHHH	11.93	21082442
81	Phosphorylation	MHQCQGTSESSKKQK HEECCCCCCCHHHHH	42.16	21082442
108	Phosphorylation	VKKKMLYSSSFDALK HHHHHHHCCCHHHHH	18.62	27626673
115	Acetylation	SSSFDALKKSLVGVQ CCCHHHHHHHHHHHH	41.87	21791702
123	Acetylation	KSLVGVQKYIQATDL HHHHHHHHHHHHCCC	41.75	21791702
128	Phosphorylation	VQKYIQATDLSEASR HHHHHHHCCCHHHHH	22.54	22817900
141	Acetylation	SREAVEEKLRATDRQ HHHHHHHHHHHHCCC	29.75	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
3	S	Phosphorylation	Kinase	LIMK1	Q8IR79	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CADF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CADF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACT6_DROME	Act88F	physical	14605208
FL2D_DROME	fl(2)d	physical	14605208
F10A1_DROME	HIP-R	physical	22036573
F10A2_DROME	HIP-R	physical	22036573
TNG2_DROME	Tango2	physical	22036573
WDR1_DROME	flr	genetic	18423434
SSH_DROME	ssh	genetic	18423434

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.