F10A2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F10A2_DROME
• UniProt AC: Q86DS1
• Protein Name: Hsc70-interacting protein 2 {ECO:0000250|UniProtKB:P50503, ECO:0000312|EMBL:AAP31294.1}
• Gene Name: HIP-R {ECO:0000303|PubMed:19333534}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 377
• Subcellular Localization: Cytoplasm .
• Protein Description: One HIP oligomer binds the ATPase domains of at least two Hsc70 molecules dependent on activation of the Hsc70 ATPase by Hsp40. Stabilizes the ADP state of Hsc70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of Hsc70 with various target proteins (By similarity)..
• Protein Sequence: MAFTMQTGDLKKLKYFIDFALENPTFLNMPQLQFVKDFVEKFGGTVPPGQFNGGSAGGKCPFGGVAGAKANEPANAPEDSEDEKSLSDPESDVELDMEGVIEADSDPAQPMGNYSKKATEEEVEQASELRAQAASAYGQQKFDEAIALYTKAIELSPGNALFHAKRGQAFLKLKKPNACIRDCDVALELNSDLAAGYKFRGRARRLLGDFELAAHDLRQACKLDFDEETDEWLKEVTPNAKKIEQHRLKQERRQAERKIKERQRDQRRARKEQEKHNASSGGSSGEFSGGNPGNGNMSDILGAMSDPEVSAAIQDILSNPGNITKYASNPKIYNLIKKIVPGGDVGAAFGQAGEKAGKPSEPKPKKDSADFVDDGLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	PANAPEDSEDEKSLS CCCCCCCCCCHHHCC	45.33	21082442
85	Phosphorylation	EDSEDEKSLSDPESD CCCCCHHHCCCCCCC	30.93	19429919
87	Phosphorylation	SEDEKSLSDPESDVE CCCHHHCCCCCCCCE	59.20	19429919
91	Phosphorylation	KSLSDPESDVELDME HHCCCCCCCCEECCC	52.96	19429919
156	Phosphorylation	YTKAIELSPGNALFH HHHCHHCCCCCHHHE	20.26	19429919
368	Phosphorylation	EPKPKKDSADFVDDG CCCCCCCCCCCCCCC	38.32	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F10A2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F10A2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F10A2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GCYDB_DROME	Gyc-89Db	physical	22036573
Y5902_DROME	CG5902	physical	22036573
VNNL1_DROME	vanin-like	physical	22036573
GCYDA_DROME	Gyc-89Da	physical	22036573
OTU1_DROME	CG4603	physical	22036573
PANG1_DROME	pan	physical	22036573
PANG2_DROME	pan	physical	22036573
TAD2B_DROME	Ada2b	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, AND MASSSPECTROMETRY.
PubMed: 17372656