PANG2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PANG2_DROME
• UniProt AC: Q8IMA8
• Protein Name: Protein pangolin, isoform J
• Gene Name: pan {ECO:0000312|FlyBase:FBgn0085432}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1192
• Subcellular Localization: Nucleus .
• Protein Description: Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes..
• Protein Sequence: MPHCGTTNSEINLNSNELISYQKKKSNEDLQKKHDKKCSINLKTSQVPDGGFNNQYTQLTANKIEQYNCNDLDKVCIVPSSRSDGMEASFSELLLSPNKLISQPWQTAEEIENWQNDSFRQRNEMFSCIYTNSMLNQQPCSQQQLLATQLLYARLLRSQLAEREFHSNKFNMVHYSGSKKTMLREDELLSTPSSQDNNNNIKLIKDIENSISCVDPPLFEFSNVHQRAEQKNKQDDKNCYSPKLKSNKEALDGYDLQHTCDFIREQKNILIDIKKKLDNLSDSSGKFRKRLSVRQSHIEVNNGSNSALEESVRRQLNGNRKSIENLLEEVKRLYNQWSSAELYYVRSLQRLGLPSEEDGEYTSTPTHTIMALAAIALSNESILPQKTNAVHSKIPDVESESDFFLTSAKPKTLVEIEDIILQLASSVNMHQSSSASTPHESYSDSVKSDCEESNSAPTCIWHSTRQTFRHKKDVEPCSTAAEIILEYASLSSSSNIETSRLLTSASNLTDVTENYNVTTQLPIVFNYNRESSAESIVTDPLLVPEFSTAPSTPSTGSNSGCSTGMVSGIFGLSQNRRKQRLARHIETLTTNSFKSNAIRGNVDNEITNQLKTSPSIRALPTENVSHLITKTLSSANASLTAQELSITNLFKERLCALQGNAGSMKTEIFPMIDAPYDLSIGSKTKHMNLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGYVSKKKKRKKDRSTTDSGGNNMKKCRARFGLDQQSQWCKPCRRKKKCIRYMEALNGNGPAEDGSCFDEHGSQLSDDDEDDYDDDKLGGSCGSADETNKIEDEDSESLNQSMPSPGCLSGLSSLQSPSTTMSLASPLNMNANSATNVIFPASSNALLIVGADQPTAQQRPTLVSTSGSSSGSTSSISTTPNTSSTVSPVTCMTGPCLGSSQERAMMLGNRFSHLGMGLSPPVVSTSTSKSEPFFKPHPTVCNNPIFALPSIGNCSLNISSMPNTSRNPIGANPRDINNPLSINQLTKRREYKNVELIEASESKTIVAHAATSIIQHVAVNGYHANHSLLNSNLGHLHHQLNNRTENPNRSEQTMLSVSNHSVNSSECHKESDSQAIVSSNPPNAGSSDNGVISVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1009	Phosphorylation	MMLGNRFSHLGMGLS HHHCCHHHHCCCCCC	17.99	19429919
1016	Phosphorylation	SHLGMGLSPPVVSTS HHCCCCCCCCEEECC	22.79	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PANG2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PANG2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PANG2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARM_DROME	arm	physical	17113388
EWG_DROME	ewg	genetic	22028028
RBF_DROME	Rbf	genetic	15001704
ARM_DROME	arm	genetic	11128568
ARM_DROME	arm	genetic	21399610
OVO_DROME	ovo	genetic	10421370
GROU_DROME	gro	genetic	9783586
GROU_DROME	gro	genetic	11128568
2ABA_DROME	tws	genetic	14973271
ARM_DROME	arm	physical	10075848
ARM_DROME	arm	physical	11955446
ARM_DROME	arm	physical	9039917
ARM_DROME	arm	physical	9751710
ARM_DROME	arm	physical	16169192
MAD_DROME	Mad	physical	21990430

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.