ARM_DROME - dbPTM
ARM_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARM_DROME
UniProt AC P18824
Protein Name Armadillo segment polarity protein
Gene Name arm
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 843
Subcellular Localization Cytoplasm . Cell membrane
Peripheral membrane protein
Cytoplasmic side . Cell junction, adherens junction . Inner surface of cell membrane and adherens junction.
Protein Description Isoform neural may associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Isoform cytoplasmic accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis..
Protein Sequence MSYMPAQNRTMSHNNQYNPPDLPPMVSAKEQTLMWQQNSYLGDSGIHSGAVTQVPSLSGKEDEEMEGDPLMFDLDTGFPQNFTQDQVDDMNQQLSQTRSQRVRAAMFPETLEEGIEIPSTQFDPQQPTAVQRLSEPSQMLKHAVVNLINYQDDAELATRAIPELIKLLNDEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAISNSNDLESTKAAVGTLHNLSHHRQGLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKMAVRLAGGLQKMVTLLQRNNVKFLAIVTDCLQILAYGNQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCSSNKPAIVDAGGMQALAMHLGNMSPRLVQNCLWTLRNLSDAATKVEGLEALLQSLVQVLGSTDVNVVTCAAGILSNLTCNNQRNKATVCQVGGVDALVRTIINAGDREEITEPAVCALRHLTSRHVDSELAQNAVRLNYGLSVIVKLLHPPSRWPLIKAVIGLIRNLALCPANHAPLREHGAIHHLVRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRMEEIVEGTVGALHILARESHNRALIRQQSVIPIFVRLLFNEIENIQRVAAGVLCELAADKEGAEIIEQEGATGPLTDLLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSIELTNSLLREDNNIWANADLGMGPDLQDMLGPEEAYEGLYGQGPPSVHSSHGGRAFHQQGYDTLPIDSMQGLEISSPVGGGGAGGAPGNGGAVGGASGGGGNIGAIPPSGAPTSPYSMDMDVGEIDAGALNFDLDAMPTPPNDNNNLAAWYDTDC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
56PhosphorylationGAVTQVPSLSGKEDE
CCEEECCCCCCCCCH		35.9914966281
199PhosphorylationSRHAIMNSPQMVAAL
HHHHHHCCHHHHHHH		10.1022817900
650PhosphorylationIIEQEGATGPLTDLL
HHHHCCCCCCHHHHH		50.6322817900
688PhosphorylationQDYKKRLSIELTNSL
CCHHHHHHHHHHHHH		20.3228490779
694PhosphorylationLSIELTNSLLREDNN
HHHHHHHHHHCCCCC		24.4422817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
56SPhosphorylationKinaseCKIALPHAP54367
GPS
56SPhosphorylationKinaseKC1D-PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARM_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARM_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PANG1_DROMEpanphysical
14605208
PANG2_DROMEpanphysical
14605208
PSA72_DROMEProsalpha4T1physical
14605208
VRET_DROMEvretphysical
14605208
MED17_DROMEMED17physical
12021283
CADE_DROMEshgphysical
12551951
BCL9_DROMElgsphysical
11912189
ISWI_DROMEIswiphysical
19713963
CAF1_DROMECaf1physical
19713963
CTNA_DROMEalpha-Catphysical
22036573
SGG_DROMEsgggenetic
10581282
SGG_DROMEsgggenetic
12559488
SGG_DROMEsgggenetic
10924470
OVO_DROMEovogenetic
10421370
DSH_DROMEdshgenetic
10581282
DLG1_DROMEdlg1genetic
10581282
HEP_DROMEhepgenetic
10903184
DS_DROMEdsgenetic
10581282
DECA_DROMEdppgenetic
10903184
AFF4_DROMElilligenetic
10581282
FAT_DROMEftgenetic
10581282
WNTG_DROMEwggenetic
10581282
CDK1_DROMEcdc2genetic
10581282
DA_DROMEdagenetic
12091309
FAS3_DROMEFas3genetic
10581282
SPITZ_DROMEspigenetic
10924470
TSH_DROMEtshgenetic
9707400
MAM_DROMEmamgenetic
18073442
CADE_DROMEshggenetic
10581282
CADE_DROMEshggenetic
9635189
EGFR_DROMEEgfrgenetic
10581282
EGFR_DROMEEgfrgenetic
11258709
RHOM_DROMErhogenetic
10581282
ARP3_DROMEArp3genetic
22266901
CCNA_DROMECycAgenetic
10581282
M3K7_DROMETak1genetic
10903184
BRM_DROMEbrmgenetic
11532957
GIL_DROMEaosgenetic
10581282
GIL_DROMEaosgenetic
11258709
HID_DROMEWgenetic
10924470
RUVB2_DROMEreptgenetic
11080158
ERF1_DROMEeRF1genetic
14573473
PSN_DROMEPsngenetic
10924470
TRBID_DROMEtrbdgenetic
18281465
CTBP_DROMECtBPgenetic
21468031
CTBP_DROMECtBPgenetic
16710294
CRB_DROMEcrbgenetic
10581282
GROU_DROMEgrogenetic
9783586
MPIP_DROMEstggenetic
10581282
MPIP_DROMEstggenetic
12559488
AXN_DROMEAxngenetic
11493532
PYGO_DROMEpygogenetic
11988739
PYGO_DROMEpygogenetic
12015286
CI_DROMEcigenetic
11784100
CI_DROMEcigenetic
9783586
PANG1_DROMEpangenetic
9783586
PANG2_DROMEpangenetic
9783586
PANG1_DROMEpangenetic
10924470
PANG2_DROMEpangenetic
10924470
PANG1_DROMEpangenetic
11258709
PANG2_DROMEpangenetic
11258709
PANG1_DROMEpangenetic
11532957
PANG2_DROMEpangenetic
11532957
BCL9_DROMElgsgenetic
11955446
SPEN_DROMEspengenetic
12783785
SPEN_DROMEspengenetic
18174108
JNK_DROMEbskgenetic
10903184
NKD_DROMEnkdgenetic
10581282
ABL_DROMEAblgenetic
9635189
2ABA_DROMEtwsgenetic
10581282
RUVB1_DROMEpontgenetic
11080158
DSH_DROMEdshphysical
25063455
MED21_DROMEMED21physical
12556495
MY31D_DROMEMyo31DFphysical
16598259
CADN_DROMECadNphysical
9635189
CADE_DROMEshgphysical
25968313
CADE_DROMEshgphysical
8794868
CADE_DROMEshgphysical
8943306
CADE_DROMEshgphysical
9635189
NFT1_DROMENitFhitphysical
27462437
CDK8_DROMECdk8physical
12556495
CTNA_DROMEalpha-Catphysical
25968313
CTNA_DROMEalpha-Catphysical
8227220
CTNA_DROMEalpha-Catphysical
8794868
CTNA_DROMEalpha-Catphysical
8943306
MED31_DROMEMED31physical
12556495
FOXO_DROMEfoxophysical
26936649
MED17_DROMEMED17physical
12556495
EXOC5_DROMESec10physical
16224820
MYS9_DROMEjarphysical
12134162
AXN_DROMEAxnphysical
12636921
AXN_DROMEAxnphysical
19850033
PANG1_DROMEpanphysical
10075848
PANG2_DROMEpanphysical
10075848
PANG1_DROMEpanphysical
21393571
PANG2_DROMEpanphysical
21393571
PANG1_DROMEpanphysical
9118222
PANG2_DROMEpanphysical
9118222
BCL9_DROMElgsphysical
11955446
BCL9_DROMElgsphysical
14612447
BCL9_DROMElgsphysical
15294866
BCL9_DROMElgsphysical
16169192
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARM_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-650; SER-688 ANDSER-694, AND MASS SPECTROMETRY.

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