TRBID_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRBID_DROME
• UniProt AC: Q9VH90
• Protein Name: Ubiquitin thioesterase trabid
• Gene Name: trbd
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 778
• Protein Description: Positive regulator of the Wnt signaling pathway. Specifically cleaves 'Lys-63'-linked ubiquitin chains. May act by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription (By similarity). Required for an efficient wg response, but not for other signaling responses, in the eye..
• Protein Sequence: MCDTKDDAQKWKCETCTYENYPSSLKCTMCQASKPLLNEDIFRLSPAQESCTVAEEAAAVEVAVMSPTPSSTCYSLQPQSQARQSNVADSEKWPCKVCTYLNWPRSLRCVQCCTKRGGEAIERGKKDMDNEADGDRAGEALQALRISGSEENLANKPVQLIGATASHRLSLSRGIDDATHLNNLANASHNQSQSQHRQPVLQQQMQLQLQPQQQRESSSSAAVPPQQQKQCYVSKWACNSCTYENWPRSIKCSMCGKTREREISGSQNDLHASSSLNSQEENQQQLQQPNVDTVSVNNSFNKKHIYQLGSSETINNCDTLQERQERRQRQIRRQVDWQWLNACLGVVENNYSAVEAYLSCGGNPARSLTSTEIAALNRNSAFDVGHTLIHLAIRFHREEMLPMLLDQISGSGPGIKRVPSYVAPDLAADIRRHFANTLRLRKSGLPCHYVQKHATFALPAEIEELPIPIQEQLYDELLDRDAQKQLETPPPALNWSLEITARLSSRMFVLWNRSAGDCLLDSAMQATWGVFDRDNILRRALADTLHQCGHVFFTRWKEYEMLQASMLHFTLEDSQFEEDWSTLLSLAGQPGSSLEQLHIFALAHILRRPIIVYGVKYVKSFRGEDIGYARFEGVYLPLFWDQNFCTKSPIALGYTRGHFSALVPMEPFTRIDGRRDDVEDVTYLPLMDCELKLLPIHFLTQSEVGNEESMMRQWLDVCVTDGGLLVAQQKLSKRPLLVAQMLEEWLNHYRRIAQVITAPFIRRPQITHYSSDGDSDEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
147	Phosphorylation	ALQALRISGSEENLA HHHHHHHCCCHHHHC	29.81	19429919
149	Phosphorylation	QALRISGSEENLANK HHHHHCCCHHHHCCC	34.64	19429919
770	Phosphorylation	RPQITHYSSDGDSDE CCCCCCCCCCCCCCC	17.85	22817900
771	Phosphorylation	PQITHYSSDGDSDEE CCCCCCCCCCCCCCC	38.15	22817900
775	Phosphorylation	HYSSDGDSDEE---- CCCCCCCCCCC----	53.07	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRBID_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRBID_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRBID_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
M3K7_DROME	Tak1	physical	24586180

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-770; SER-771 ANDSER-775, AND MASS SPECTROMETRY.
PubMed: 18327897