RUVB2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RUVB2_DROME
• UniProt AC: Q9V3K3
• Protein Name: RuvB-like helicase 2
• Gene Name: rept {ECO:0000312|EMBL:AAF49182.1, ECO:0000312|FlyBase:FBgn0040075}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 481
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth.; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair..
• Protein Sequence: MAETEKIEVRDVTRIERIGAHSHIRGLGLDDVLEARLVSQGMVGQKDARRAAGVVVQMVREGKIAGRCILLAGEPSTGKTAIAVGMAQALGTETPFTSMSGSEIYSLEMSKTEALSQALRKSIGVRIKEETEIIEGEVVEIQIERPASGTGQKVGKVTLKTTEMETNYDLGNKIIECFMKEKIQAGDVITIDKASGKVNKLGRSFTRARDYDATGAQTRFVQCPEGELQKRKEVVHTVTLHEIDVINSRTHGFLALFSGDTGEIKQEVRDQINNKVLEWREEGKAEINPGVLFIDEVHMLDIECFSFLNRALESDMAPVVVMATNRGITRIRGTNYRSPHGIPIDLLDRMIIIRTVPYSEKEVKEILKIRCEEEDCIMHPDALTILTRIATDTSLRYAIQLITTANLVCRRRKATEVNTEDVKKVYSLFLDENRSSKILKEYQDDYMFSEITEEVERDPAAGGGAKRRVEGGGGDAQPMEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
180	Acetylation	KIIECFMKEKIQAGD HHHHHHHHHCCCCCC	35.29	21791702
361	Acetylation	RTVPYSEKEVKEILK EECCCCHHHHHHHHH	62.96	21791702
423	Acetylation	EVNTEDVKKVYSLFL CCCHHHHHHHHHHHC	49.17	21791702
436	Phosphorylation	FLDENRSSKILKEYQ HCCCCCCHHHHHHHH	22.07	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RUVB2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RUVB2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RUVB2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RUVB1_DROME	pont	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.