CDK1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDK1_DROME
• UniProt AC: P23572
• Protein Name: Cyclin-dependent kinase 1
• Gene Name: Cdk1 {ECO:0000312|FlyBase:FBgn0004106}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 297
• Subcellular Localization: Nucleus.
• Protein Description: Plays a key role in the control of the eukaryotic cell cycle. [PubMed: 2120044]
• Protein Sequence: MEDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGFQSGLVRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MEDFEKIEKIGEG --CCCHHHHHCCCCC	57.04	21791702
14	Phosphorylation	IEKIGEGTYGVVYKG HHCCCCCCCEEEEEC	16.89	21082442
15	Phosphorylation	EKIGEGTYGVVYKGR HCCCCCCCEEEEECC	20.84	21082442
160	Phosphorylation	FGIPVRIYTHEIVTL HCCCEEEEECCEEEE	7.47	19429919
161	Phosphorylation	GIPVRIYTHEIVTLW CCCEEEEECCEEEEE	15.63	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
161	T	Phosphorylation	Kinase	CAK	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDK1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDK1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCNC_DROME	CycC	physical	15575970
GLIS2_DROME	sug	physical	15575970
TWINE_DROME	twe	physical	15575970
L2AM_DROME	amd	physical	15575970
CRBN_DROME	CG3925	physical	15575970
CCNE_DROME	CycE	physical	15575970
WEE1_DROME	Wee1	physical	8573790
CCNB3_DROME	CycB3	physical	9851980
CKS1_DROME	Cks30A	physical	22036573
CCNB3_DROME	CycB3	physical	22036573
ORC1_DROME	Orc1	physical	16188887
ORC2_DROME	Orc2	physical	16188887
CKS1_DROME	Cks30A	genetic	16033797
CCNB_DROME	CycB	genetic	24214341
CCNA_DROME	CycA	genetic	10320477
Z600_DROME	Z600	genetic	17431409
CCNB_DROME	CycB	physical	11581162
CCNB_DROME	CycB	physical	24214341
CCNB_DROME	CycB	physical	8156587
CCNB_DROME	CycB	physical	8980229
CCNB_DROME	CycB	physical	9851980
CCNA_DROME	CycA	physical	17431409
CCNA_DROME	CycA	physical	24214341
CCNA_DROME	CycA	physical	8156587
CCNA_DROME	CycA	physical	8980229
CCNA_DROME	CycA	physical	11027291
Z600_DROME	Z600	physical	17431409

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; TYR-15; TYR-160 ANDTHR-161, AND MASS SPECTROMETRY.
PubMed: 18327897