CCNA_DROME - dbPTM
CCNA_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CCNA_DROME
UniProt AC P14785
Protein Name G2/mitotic-specific cyclin-A
Gene Name CycA
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 491
Subcellular Localization
Protein Description Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the Cdk1 and Cdk2 protein kinases to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis..
Protein Sequence MASFQIHQDMSNKENPGIKIPAGVKNTKQPLAVIGGKAEKNALAPRANFAVLNGNNNVPRPAGKVQVFRDVRNLNVDENVEYGAKKSNVVPVVEQFKTFSVYEDNNDTQVAPSGKSLASLVDKENHDVKFGAGQKELVDYDLDSTPMSVTDVQSPMSVDRSILGVIQSSDISVGTETGVSPTGRVKELPPRNDRQRFLEVVQYQMDILEYFRESEKKHRPKPLYMRRQKDISHNMRSILIDWLVEVSEEYKLDTETLYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEIYPPEVGEFVFLTDDSYTKAQVLRMEQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYISELSLMEGETYLQYLPSLMSSASVALARHILGMEMWTPRLEEITTYKLEDLKTVVLHLCHTHKTAKELNTQAMREKYNRDTYKKVAMMESVEMSKDDFDQLCEAYNCKQKEDEHQQPDINTKSNVNLFYKF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37AcetylationPLAVIGGKAEKNALA
CEEEECCHHHHCCCC		48.4321791702
108PhosphorylationVYEDNNDTQVAPSGK
EEECCCCCEECCCCC		27.3721082442
116PhosphorylationQVAPSGKSLASLVDK
EECCCCCCHHHHHCC		32.4722817900
150PhosphorylationDSTPMSVTDVQSPMS
CCCCCCCCCCCCCCC		24.1319429919
154PhosphorylationMSVTDVQSPMSVDRS
CCCCCCCCCCCCCHH		23.5519429919
157PhosphorylationTDVQSPMSVDRSILG
CCCCCCCCCCHHHHH		25.0119429919
483PhosphorylationQPDINTKSNVNLFYK
CCCCCCCCCCEEEEC		43.9321082442
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CCNA_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CCNA_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CCNA_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SCN60_DROMENaCP60Ephysical
14605208
BCD_DROMEbcdphysical
15575970
GUS_DROMEgusphysical
15575970
CEG1A_DROMECenG1Aphysical
15575970
ENA_DROMEenaphysical
15575970
MED15_DROMEMED15physical
15575970
ARA_DROMEaraphysical
15575970
ECR_DROMEEcRphysical
15575970
CKS1_DROMECks30Aphysical
22036573
CDK1_DROMEcdc2physical
22036573
RUX_DROMEruxphysical
22036573
CCNB_DROMECycBphysical
22036573
CCNB3_DROMECycB3physical
22036573
UMPS_DROMEr-lphysical
22036573
HSP23_DROMEHsp23physical
22036573
HSP26_DROMEHsp26physical
22036573
RUX_DROMEruxphysical
11027291
CDK2_DROMEcdc2cphysical
11027291
CDK1_DROMEcdc2physical
11027291
CORT_DROMEcortphysical
24019759
RUX_DROMEruxgenetic
11231149
CDK1_DROMEcdc2genetic
11369230
CCNE_DROMECycEgenetic
16854973
CCNB_DROMECycBgenetic
12756185
CCNB_DROMECycBgenetic
8428595
BAM_DROMEbamgenetic
10644410
CDK1_DROMEcdc2physical
17431409
CDK1_DROMEcdc2physical
8156587
Z600_DROMEZ600physical
17431409
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CCNA_DROME

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Related Literatures of Post-Translational Modification

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