SCN60_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCN60_DROME
• UniProt AC: Q9W0Y8
• Protein Name: Sodium channel protein 60E
• Gene Name: NaCP60E
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2844
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Plays a role in processing of olfactory information during the olfactory avoidance response..
• Protein Sequence: MSDDQATFNDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDTFIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSKDFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEAPRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPIDDVGAPIDVNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDRQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDDQATFN ------CCCCCCCCC	62.29	27794539
282	N-linked_Glycosylation	QVPTDWTNVSHTDWQ CCCCCCCCCCCCCEE	29.10	-
293	N-linked_Glycosylation	TDWQIWVNDTDNWLY CCEEEEECCCCCCCC	31.31	-
311	N-linked_Glycosylation	ELPVLCGNLTGARHC CCCEECCCCCCCCCC	33.17	-
421	Phosphorylation	LLDHRDDSTFSFDPS HCCCCCCCCCCCCHH	35.32	27794539
422	Phosphorylation	LDHRDDSTFSFDPSV CCCCCCCCCCCCHHH	30.23	27794539
424	Phosphorylation	HRDDSTFSFDPSVLN CCCCCCCCCCHHHHC	28.91	27794539
1193	Phosphorylation	RKSLDRLSQSSGQSQ HHHHHHHHHCCCHHH	34.42	27794539
1195	Phosphorylation	SLDRLSQSSGQSQRS HHHHHHHCCCHHHHH	46.85	27794539
1196	Phosphorylation	LDRLSQSSGQSQRSL HHHHHHCCCHHHHHH	32.80	27794539
1324	Phosphorylation	ERKLSNLSEPSPAAD HHHHHCCCCCCHHHH	10.28	27794539
1327	Phosphorylation	LSNLSEPSPAADEAT HHCCCCCCHHHHHHH	29.15	27794539
1511	Phosphorylation	LSLKSTNSYENLLIQ CCCCCCCHHHHHHHH	32.07	27794539
1540	Phosphorylation	TPPTSLKSSIEPPTL CCCCCCCCCCCCCCH	27.05	27794539
1541	Phosphorylation	PPTSLKSSIEPPTLA CCCCCCCCCCCCCHH	40.32	27794539
1778	N-linked_Glycosylation	EDINLDKNKTLKRVL HHCCCCCCHHHHHHH	1.96	-
1789	N-linked_Glycosylation	KRVLYWINFSFCLIF HHHHHHHHHHHHHHH	15.76	-
1930	N-linked_Glycosylation	KWDCIEQNYTWINSK CCCHHHCCCEEECCC	5.67	-
2643	Phosphorylation	RHQAVGGGSAPSRKR HCCCCCCCCCCCHHH	27.38	19060867
2666	Phosphorylation	PPLERGLSAQSALRV CCCCCCCCHHHHHHH	4.48	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCN60_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCN60_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCN60_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAFAB_DROME	Taf10b	physical	14605208
FLNA_DROME	cher	physical	14605208
PABP_DROME	pAbp	physical	14605208
LOLAL_DROME	lolal	physical	14605208
SALM_DROME	salm	physical	14605208
PP2B2_DROME	Pp2B-14D	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.