PP2B2_DROME - dbPTM
PP2B2_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PP2B2_DROME
UniProt AC Q27889
Protein Name Serine/threonine-protein phosphatase 2B catalytic subunit 2
Gene Name Pp2B-14D
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 570
Subcellular Localization
Protein Description Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin..
Protein Sequence MSSNNQSSSVAQAATSARTVSAGSAEATDANSTASNNNNNSSSTAAAGNNSDNSSPTTGTGTGASTGKLHGGHTAVNTKERVVDSVPFPPSHKLTLAEVFDQRTGKPNHELLKQHFILEGRIEEAPALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSDDEAALRKEVIRNKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQSLKNAMQGFSPNHKITSFAEAKGLDAVNERMPPRRDQPPTPSEDPNQHSQQGGKNGAGHG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
453PhosphorylationEESEEPLSDDEAALR
CCCCCCCCCCHHHHH		54.4527794539
479PhosphorylationGKMARVFSVLREESE
HHHHHHHHHHHHHCC		19.8621082442
495PhosphorylationVLQLKGLTPTGALPL
HHHHCCCCCCCCCCC		27.7221082442
511PhosphorylationALSGGKQSLKNAMQG
HHCCHHHHHHHHHCC		44.8121082442
520PhosphorylationKNAMQGFSPNHKITS
HHHHCCCCCCCCCCC		31.4522817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PP2B2_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PP2B2_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PP2B2_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SGG_DROMEsgggenetic
24086147
MEF2_DROMEMef2genetic
25081566
SPY_DROMEstygenetic
12019233
SPY_DROMEstygenetic
25081566
GAP1_DROMERasGAP1genetic
12019233
RAS1_DROMERas85Dgenetic
12019233
GLAS_DROMEglgenetic
12019233
CANB1_DROMECanBgenetic
12019233
CANB2_DROMECanB2genetic
12019233
CANB2_DROMECanB2genetic
20561515
CANB2_DROMECanB2genetic
25081566
SRA_DROMEsragenetic
20561515
SRA_DROMEsragenetic
21900555
SRA_DROMEsragenetic
16860743
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PP2B2_DROME

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Related Literatures of Post-Translational Modification

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