| UniProt ID | GAP1_DROME | |
|---|---|---|
| UniProt AC | P48423 | |
| Protein Name | GTPase-activating protein | |
| Gene Name | RasGAP1 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1163 | |
| Subcellular Localization | ||
| Protein Description | Inhibitory regulator of the Ras-cyclic AMP pathway. May function as a negative regulator of Ras85D/Ras1 in the sev signaling pathway. Acts cell autonomously in cone cell precursors as a negative regulator of R7 photoreceptor cell determination.. | |
| Protein Sequence | MLLKKKRYMFDERDDNNINSPVAVEPSSNNNKMADTREVRIEEQLKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRRFRYLTIYLWDRDMKQDKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEVAFTEAQQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGELVSGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRKRFGRQFKQRHFRLTTHSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYKQGITRQLKYGSRQAPIGDDNYWHMMRAAGQLNQQHHQQQQHQQQQQQQQQQQLQQFQPQPVLPQMQNVRAYPYQPATSNMNAYCLHNMQYQQQRLPFHQQQQQHHQQLQQQQSQFQPLRSHQLQRHNNNLNNNNCGNGSSSSPSSTTSSVVAAPPSTTSSSQPAPPIY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 432 | Phosphorylation | SMTHSSRSLNATPRS CCCCCCCCCCCCCCC | 28.11 | 27626673 | |
| 436 | Phosphorylation | SSRSLNATPRSCATP CCCCCCCCCCCCCCC | 20.40 | 27626673 | |
| 439 | Phosphorylation | SLNATPRSCATPPGT CCCCCCCCCCCCCCC | 14.87 | 27626673 | |
| 446 | Phosphorylation | SCATPPGTRLSVDST CCCCCCCCEEEECCC | 33.92 | 25749252 | |
| 650 | Phosphorylation | SNREVRYSVVSGFIF CCCCCCCEEECCCHH | 12.89 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GAP1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GAP1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GAP1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HSP7D_DROME | Hsc70-4 | genetic | 9178011 | |
| HMPB_DROME | pb | genetic | 9178011 | |
| RAS1_DROME | Ras85D | genetic | 8901596 | |
| RAS1_DROME | Ras85D | genetic | 9178011 | |
| RSSA_DROME | sta | physical | 22028469 | |
| CAZ_DROME | caz | physical | 22028469 | |
| RS5A_DROME | RpS5a | physical | 22028469 | |
| RL24_DROME | RpL24 | physical | 22028469 | |
| HSP83_DROME | Hsp83 | physical | 22028469 | |
| CPSF6_DROME | CG7185 | physical | 22028469 | |
| SQD_DROME | sqd | physical | 22028469 | |
| TTF2_DROME | lds | physical | 22028469 | |
| LARP_DROME | larp | physical | 22028469 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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