TTF2_DROME - dbPTM
TTF2_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TTF2_DROME
UniProt AC P34739
Protein Name Transcription termination factor 2
Gene Name lds
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1061
Subcellular Localization Nucleus .
Protein Description DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template..
Protein Sequence MSSENSEYYSDKEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSETAESEKSDESDNSQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSKLTIDDLKGLFGM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationSENSEYYSDKEEDSV
CCCCCCCCCCCCCCC		41.1119429919
22PhosphorylationDSVVNNSSLGRSRKS
CCCCCCCHHCCCHHH		36.6519429919
108PhosphorylationRKPLGIPSDSEDEED
CCCCCCCCCCCCCHH		52.4221082442
110PhosphorylationPLGIPSDSEDEEDEL
CCCCCCCCCCCHHHH		51.8121082442
123PhosphorylationELEQRALSPSTRMSI
HHHHHHCCHHHCCEE		18.8022668510
125PhosphorylationEQRALSPSTRMSITG
HHHHCCHHHCCEECC		25.8527626673
129PhosphorylationLSPSTRMSITGVRPQ
CCHHHCCEECCCCCC		17.4430478224
131PhosphorylationPSTRMSITGVRPQDL
HHHCCEECCCCCCCC		23.4730478224
139PhosphorylationGVRPQDLSDDDSEIE
CCCCCCCCCCCCCCC		47.4822668510
143PhosphorylationQDLSDDDSEIEYSDE
CCCCCCCCCCCCCHH		47.6822668510
147PhosphorylationDDDSEIEYSDEVQEG
CCCCCCCCCHHHCCC		27.3822668510
148PhosphorylationDDSEIEYSDEVQEGP
CCCCCCCCHHHCCCC		17.9522668510
214PhosphorylationETPIEILSSTDDDAT
CCCEEEECCCCCCCC		36.5319429919
215PhosphorylationTPIEILSSTDDDATT
CCEEEECCCCCCCCC		32.2019429919
216PhosphorylationPIEILSSTDDDATTN
CEEEECCCCCCCCCC		39.8219429919
243PhosphorylationSKSLSPRSSAGASVV
CCCCCCCCCCCCCEE		28.1119429919
244PhosphorylationKSLSPRSSAGASVVK
CCCCCCCCCCCCEEE		31.8119429919
257PhosphorylationVKTSKNLSQPTIQAV
EECCCCCCCHHHHHH		43.4322817900
269PhosphorylationQAVLKQKTSPAAPRR
HHHHHHCCCCCCCCH		37.1322817900
270PhosphorylationAVLKQKTSPAAPRRS
HHHHHCCCCCCCCHH		21.4122817900
281PhosphorylationPRRSRIKSEDQKVVS
CCHHHCCCCHHHHHH		43.9919429919
372PhosphorylationLNPPRAPSIDTLDWD
CCCCCCCCCCCCCHH		31.9219429919
418PhosphorylationSLKDLHVSLEDLPGP
HHHHHCCCHHHCCCC		18.4622817900
510PhosphorylationDKNKKRKSVTGWKSK
HHHCCCCCCCCCHHC		29.0127626673
527PhosphorylationKDTRRGGTLVVCPAS
CCCCCCCEEEEEEHH		21.1421082442
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TTF2_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TTF2_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TTF2_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TTF2_DROME !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TTF2_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108; SER-110; SER-214;SER-215 AND THR-216, AND MASS SPECTROMETRY.

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