LARP_DROME - dbPTM
LARP_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LARP_DROME
UniProt AC Q9VAW5
Protein Name La-related protein 1
Gene Name larp
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1673
Subcellular Localization Cytoplasm, cytosol .
Protein Description RNA-binding protein required during male meiosis and development of the syncytial embryo. Binds poly-(A) tails of mRNAs and regulates their expression by regulating their stability or translation..
Protein Sequence MSSKEETPSTGGAAPVATVAASGSATTSYANVVQNLETKKSGTSNTTTTTARATVDNKENQPNLKSFKSWSEEAAAAEAAGESPIVGSVSLAQTGEKRAAASGGDNTAENSSELDDNNDFVPVLSHHRRDRKKARKEKPRDQQPAGGRGDGQKPQQAGGRRVPGSSDTERKSVRPRAPRGGSPRKSAAGAAGAAGSNAGAVSSAVPGGPKVHKDRKDTSPSASIEGAGSSGNEAKSADGDQQAGEKGAAGAAPPPKRFIAAPPPKVNAWKISAKQSGSPKAGTSPLDKRVLQPKAQQQQQQTKQTASQNNNAQNTASNKKTQQQQQPQQGATTTTQTTTAAAAAATAAAAATAATTSAAAATSSAAAVPAATTETATTTTVDASQADALAKVVVKDKKKVNQKASDFSNVGDWPTLIGGTSGSGKATSNEPKRNPTKKQQSAKTAAAVAASSNTTSSEVATESNVAGTTSSSNSNPSSSTTTTNTTTNSQATTAPVASTSHDAKAQRDAEPAANSAAGTTGTAAGPALTKKIPKHKWRPLPIDLAKSSRPKPIGGRPNRRFSDDIADQRRPPRVYHDRQPGAGGAGVESRHPHAGRHPYGSRPATATSERVDSWRSSSSTTTAAFDEQRSGAAGGAGAAGTGVGSATRGPRRYRTPYRGGRQGRGGFSRQGPGRPTYRIPRHLLASGEYANYLPADAAGADSQSSYVLMGTHYFGNVPAAYIELDANSIKEAIKKQVEYYFSVDNLTGDFFLRRKMDPEGYIPVTLIASFHRVLALTTDVAVIVNAIKESDKLELFEGYKVRTKTTPTTWPITEVPEVNEGEPKAIGTLEQEQLEQNDGQEKLEEQTEADSPPPILTSAMATKPLNSIPPPPMPRNPQNLVPKMLQDKQQSRSSTIAALNSVNAISALTQQVEGGAAELAGHLSGLAESVKPKSTSTPDKRNAASAGNGAGSAAALVAEPEGIWKEVKRRSKTNAIKENATTPPQQQQPPLSQTLNNNNDNVKTNNTSSKSKSSSNNAPSNASSSATVCVTTNNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTHSKSSSKTAAPPSAQCHAEKEELDFQFDEELMDPLPPGTGRINNFTENFSDDDESDYEFADRDINKLLIVAQVGRAPKHEGYDRTADFTSRTKITQDLENIINDGLVNYEEDLWTTTNVVADYKTVNVISQADFEKLAGGRNKSVLPPQVVPPPPPFEEDLDETLVGDTTLNSTLNNTLKSRRARFYAAPNSHSIDPRTPRKRKLRHTANPPVEAHVGWLLDTVEHRPRTTSMGSSAGTSPTASSYGSFGSSVPQSLPVFQHPSHALLKENNFTQQAYHKYHSRCLKERRRLGYGQSQEMNTLYRFWSFFLRENFNKSMYNEFRSLALEDAGNGFRYGLECLFRFFSYGLEKKFRPNIYQDFQDETIADYETGQLYGLEKFWAFLKYYKNGEKLEVQPKLAEYLKSFKNIEDFRVVEPEINEMLQGVGSLNPGRQLNRHRSVSESDGTAVIAAGGRRLNTTITNRSDYVGRLLQQQHQQQQQQQHHQYQQGYGGYNQQQNRRRTGSFGSTTVRIRSGSLGNKPQVANRNQGSQHELRRGGSNSGLAPHKRQQQQKPKPGAGSQTGSTRATTSAAATATTAASAATSTAATPAVTVSSGSSSSKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationTPSTGGAAPVATVAA
CCCCCCCCCCEEEEC		11.4518327897
54PhosphorylationTTTTARATVDNKENQ
CEEEEEEECCCCCCC		23.8818511481
66PhosphorylationENQPNLKSFKSWSEE
CCCCCHHHHHHHHHH		40.8630772175
69PhosphorylationPNLKSFKSWSEEAAA
CCHHHHHHHHHHHHH		33.5519429919
71PhosphorylationLKSFKSWSEEAAAAE
HHHHHHHHHHHHHHH		32.4219429919
83PhosphorylationAAEAAGESPIVGSVS
HHHHCCCCCCEEEEE		21.0030478224
102PhosphorylationGEKRAAASGGDNTAE
CCCCHHHCCCCCCCC		38.2819429919
107PhosphorylationAASGGDNTAENSSEL
HHCCCCCCCCCCHHC		39.8419429919
111PhosphorylationGDNTAENSSELDDNN
CCCCCCCCHHCCCCC		19.3919429919
112PhosphorylationDNTAENSSELDDNND
CCCCCCCHHCCCCCC		54.4819429919
165PhosphorylationGGRRVPGSSDTERKS
CCCCCCCCCCCCCCC		20.9719429919
166PhosphorylationGRRVPGSSDTERKSV
CCCCCCCCCCCCCCC		55.2419429919
168PhosphorylationRVPGSSDTERKSVRP
CCCCCCCCCCCCCCC		39.3721082442
182PhosphorylationPRAPRGGSPRKSAAG
CCCCCCCCCCCCCCC		25.1021082442
186PhosphorylationRGGSPRKSAAGAAGA
CCCCCCCCCCCCCCC		25.3230772175
218PhosphorylationVHKDRKDTSPSASIE
CCCCCCCCCCCCCCC		45.6419429919
219PhosphorylationHKDRKDTSPSASIEG
CCCCCCCCCCCCCCC		27.3021082442
221PhosphorylationDRKDTSPSASIEGAG
CCCCCCCCCCCCCCC		34.1219429919
223PhosphorylationKDTSPSASIEGAGSS
CCCCCCCCCCCCCCC		26.0528490779
229PhosphorylationASIEGAGSSGNEAKS
CCCCCCCCCCCCCCC		34.2419060867
230PhosphorylationSIEGAGSSGNEAKSA
CCCCCCCCCCCCCCC		44.7325749252
236PhosphorylationSSGNEAKSADGDQQA
CCCCCCCCCCCCHHH		38.3419429919
278PhosphorylationISAKQSGSPKAGTSP
EECCCCCCCCCCCCC		28.6030478224
283PhosphorylationSGSPKAGTSPLDKRV
CCCCCCCCCCCCHHH		31.8419429919
284PhosphorylationGSPKAGTSPLDKRVL
CCCCCCCCCCCHHHH		23.6519429919
338PhosphorylationATTTTQTTTAAAAAA
CCCHHHHHHHHHHHH		12.4818327897
562PhosphorylationGRPNRRFSDDIADQR
CCCCCCCCCCCCCCC		32.3421082442
608PhosphorylationSRPATATSERVDSWR
CCCCCCCCCCHHHHC		22.4218327897
616PhosphorylationERVDSWRSSSSTTTA
CCHHHHCCCCCCCCH		28.4519429919
617PhosphorylationRVDSWRSSSSTTTAA
CHHHHCCCCCCCCHH		21.5319429919
618PhosphorylationVDSWRSSSSTTTAAF
HHHHCCCCCCCCHHH		32.7119429919
619PhosphorylationDSWRSSSSTTTAAFD
HHHCCCCCCCCHHHH		31.5519429919
620PhosphorylationSWRSSSSTTTAAFDE
HHCCCCCCCCHHHHH		30.0719429919
621PhosphorylationWRSSSSTTTAAFDEQ
HCCCCCCCCHHHHHH		19.1819429919
622PhosphorylationRSSSSTTTAAFDEQR
CCCCCCCCHHHHHHC		18.9719429919
828PhosphorylationGEPKAIGTLEQEQLE
CCCCEECCCCHHHHH		22.4730772175
847PhosphorylationQEKLEEQTEADSPPP
HHHHHHHHHCCCCCC		36.1022668510
849PhosphorylationKLEEQTEADSPPPIL
HHHHHHHCCCCCCCC		26.4318327897
851PhosphorylationEEQTEADSPPPILTS
HHHHHCCCCCCCCCC		46.4819429919
854PhosphorylationTEADSPPPILTSAMA
HHCCCCCCCCCCHHC		37.2918327897
857PhosphorylationDSPPPILTSAMATKP
CCCCCCCCCHHCCCC		18.3723607784
858PhosphorylationSPPPILTSAMATKPL
CCCCCCCCHHCCCCC		16.7723607784
862PhosphorylationILTSAMATKPLNSIP
CCCCHHCCCCCCCCC		21.8023607784
867PhosphorylationMATKPLNSIPPPPMP
HCCCCCCCCCCCCCC		44.1223607784
981PhosphorylationNAIKENATTPPQQQQ
HHHHHCCCCCCHHHC		51.9519429919
982PhosphorylationAIKENATTPPQQQQP
HHHHCCCCCCHHHCC		30.4819429919
991PhosphorylationPQQQQPPLSQTLNNN
CHHHCCCHHHHCCCC		8.2518327897
992PhosphorylationQQQQPPLSQTLNNNN
HHHCCCHHHHCCCCC		27.2229892262
1045PhosphorylationATKATTKTTTTSTAT
CCCCEEEEEECCCEE		27.5518327897
1115PhosphorylationTGRINNFTENFSDDD
CCCCCCCCCCCCCCC		31.9419429919
1119PhosphorylationNNFTENFSDDDESDY
CCCCCCCCCCCHHHH		52.2721082442
1124PhosphorylationNFSDDDESDYEFADR
CCCCCCHHHHHHHCC		53.1119429919
1126PhosphorylationSDDDESDYEFADRDI
CCCCHHHHHHHCCHH		23.4019429919
1240PhosphorylationTLVGDTTLNSTLNNT
CCCCCCCHHHHHHHH		5.3118327897
1242PhosphorylationVGDTTLNSTLNNTLK
CCCCCHHHHHHHHHH		37.0718327897
1243PhosphorylationGDTTLNSTLNNTLKS
CCCCHHHHHHHHHHH		32.2230478224
1247PhosphorylationLNSTLNNTLKSRRAR
HHHHHHHHHHHHHHH		34.1930478224
1261PhosphorylationRFYAAPNSHSIDPRT
HEEECCCCCCCCCCC		19.9719429919
1263PhosphorylationYAAPNSHSIDPRTPR
EECCCCCCCCCCCCC		28.6219429919
1299PhosphorylationTVEHRPRTTSMGSSA
CCCCCCCCCCCCCCC		26.3821082442
1301PhosphorylationEHRPRTTSMGSSAGT
CCCCCCCCCCCCCCC		22.1221082442
1304PhosphorylationPRTTSMGSSAGTSPT
CCCCCCCCCCCCCCC		14.3621082442
1308PhosphorylationSMGSSAGTSPTASSY
CCCCCCCCCCCHHHC		31.1118327897
1309PhosphorylationMGSSAGTSPTASSYG
CCCCCCCCCCHHHCC		21.2421082442
1311PhosphorylationSSAGTSPTASSYGSF
CCCCCCCCHHHCCCC		38.6521082442
1315PhosphorylationTSPTASSYGSFGSSV
CCCCHHHCCCCCCCC		17.8118327897
1340PhosphorylationSHALLKENNFTQQAY
CHHHHHHCCCCHHHH		47.5318327897
1498PhosphorylationEMLQGVGSLNPGRQL
HHHHCCCCCCCCCCC		23.6729892262
1510PhosphorylationRQLNRHRSVSESDGT
CCCCCCCCCCCCCCC		24.7021082442
1512PhosphorylationLNRHRSVSESDGTAV
CCCCCCCCCCCCCEE		32.4021082442
1514PhosphorylationRHRSVSESDGTAVIA
CCCCCCCCCCCEEEE		33.5619429919
1517PhosphorylationSVSESDGTAVIAAGG
CCCCCCCCEEEEECC		23.8119429919
1573PhosphorylationQQQNRRRTGSFGSTT
HHCCCCCCCCCCCCE		35.0519429919
1575PhosphorylationQNRRRTGSFGSTTVR
CCCCCCCCCCCCEEE		26.3119429919
1578PhosphorylationRRTGSFGSTTVRIRS
CCCCCCCCCEEEEEC		20.9219429919
1579PhosphorylationRTGSFGSTTVRIRSG
CCCCCCCCEEEEECC		29.6819429919
1580PhosphorylationTGSFGSTTVRIRSGS
CCCCCCCEEEEECCC		14.9719429919
1585PhosphorylationSTTVRIRSGSLGNKP
CCEEEEECCCCCCCC		30.2919429919
1587PhosphorylationTVRIRSGSLGNKPQV
EEEEECCCCCCCCCC		34.0619429919
1601PhosphorylationVANRNQGSQHELRRG
CCCCCCCCCCCHHHC		20.7119429919
1610PhosphorylationHELRRGGSNSGLAPH
CCHHHCCCCCCCCCC		30.5519429919
1612PhosphorylationLRRGGSNSGLAPHKR
HHHCCCCCCCCCCHH		36.5629892262
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LARP_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LARP_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LARP_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PABP_DROMEpAbpgenetic
19631203
PABP_DROMEpAbpphysical
19631203
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LARP_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69; SER-102; THR-107;SER-111; SER-112; SER-219; SER-221; SER-223; SER-229; SER-230;SER-236; SER-284; SER-608; SER-1119; SER-1124; SER-1261; TYR-1315;SER-1510; SER-1512; SER-1578; SER-1585 AND SER-1610, AND MASSSPECTROMETRY.
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-69; SER-562 ANDSER-851, AND MASS SPECTROMETRY.

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