PABP_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PABP_DROME
• UniProt AC: P21187
• Protein Name: Polyadenylate-binding protein
• Gene Name: pAbp
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 634
• Protein Description: Binds the poly(A) tail of mRNA..
• Protein Sequence: MASLYVGDLPQDVNESGLFDKFSSAGPVLSIRVCRDVITRRSLGYAYVNFQQPADAERALDTMNFDLVRNKPIRIMWSQRDPSLRRSGVGNVFIKNLDRAIDNKAIYDTFSAFGNILSCKVATDEKGNSKGYGFVHFETEEAANTSIDKVNGMLLNGKKVYVGKFIPRKEREKELGEKAKLFTNVYVKNFTEDFDDEKLKEFFEPYGKITSYKVMSKEDGKSKGFGFVAFETTEAAEAAVQALNGKDMGEGKSLYVARAQKKAERQQELKRKFEELKQKRHESVFGVNLYVKNLDDTIDDDRLRIAFSPYGNITSAKVMTDEEGRSKGFGFVCFNAASEATCAVTELNGRVVGSKPLYVALAQRKEERKAHLASQYMRHMTGMRMQQLGQIYQPNAASGFFVPTLPSNQRFFGSQVATQMRNTPRWVPQVRPPAAIQGVQAGAAAAGGFQGTAGAVPTQFRSAAAGARGAQPQVQGTHAAAAAANNMRNTGARAITGQQTAAPNMQIPGAQIAGGAQQRTSNYKYTSNMRNPPVPQLHQTQPIPQQLQGKNSEKLIASLLANAKPQEQKQILGERLYPMIEHMHANLAGKITGMLLEIENSELLHMIEDQEALKAKVEEAVAVLQVHRVTEPAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	RDVITRRSLGYAYVN CHHHHHCCCEEEEEE	23.90	19429919
83	Phosphorylation	MWSQRDPSLRRSGVG EEECCCHHHHHCCCC	38.50	27626673
87	Phosphorylation	RDPSLRRSGVGNVFI CCHHHHHCCCCCHHH	31.25	19429919
252	Ubiquitination	GKDMGEGKSLYVARA CCCCCCCHHHHHHHH	32.74	31113955
283	Phosphorylation	LKQKRHESVFGVNLY HHHHHHHHHHCCEEE	19.34	19429919
297	Phosphorylation	YVKNLDDTIDDDRLR EEECCCCCCCCCCEE	26.44	18327897
358	Phosphorylation	VVGSKPLYVALAQRK EECCCHHHHHHHHCH	7.69	21082442
374	Phosphorylation	ERKAHLASQYMRHMT HHHHHHHHHHHHHHH	28.36	19429919
392	Phosphorylation	MQQLGQIYQPNAASG HHHHHCCCCCCCCCC	15.27	18281928
398	Phosphorylation	IYQPNAASGFFVPTL CCCCCCCCCCCCCCC	33.45	21082442
414	Phosphorylation	SNQRFFGSQVATQMR CCCCCCCHHHHHHHC	19.14	21082442
418	Phosphorylation	FFGSQVATQMRNTPR CCCHHHHHHHCCCCC	24.84	21082442
540	Phosphorylation	PVPQLHQTQPIPQQL CCCCCCCCCCCCHHH	26.09	21082442
552	Phosphorylation	QQLQGKNSEKLIASL HHHCCCCHHHHHHHH	39.32	21082442
558	Phosphorylation	NSEKLIASLLANAKP CHHHHHHHHHHCCCH	19.54	21082442
630	Phosphorylation	VLQVHRVTEPAN--- HHEEEECCCCCC---	35.89	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PABP_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PABP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PABP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTBP_DROME	CtBP	physical	14605208
MAL2_DROME	Mal-A2	physical	14605208
TAZ_DROME	Taz	physical	14605208
RGA_DROME	Rga	physical	19797087
GAWKY_DROME	gw	physical	21063388
RS27A_DROME	RpS27A	physical	24292889
HYD_DROME	hyd	genetic	20604743
LARP_DROME	larp	genetic	19631203
CUP_DROME	cup	physical	18082158
GRK_DROME	grk	physical	23213441
BICD_DROME	BicD	physical	21782810
HAIR_DROME	h	physical	21782810
OSKA_DROME	osk	physical	21782810
GAWKY_DROME	gw	physical	19797087

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.