GRK_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRK_DROME
• UniProt AC: P42287
• Protein Name: Protein gurken
• Gene Name: grk
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 295
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Associates with the membranous cortex of yolk granules. Transiently inserted into the cell membrane, and then reinternalized during yolk uptake. cni is required for its transport to the oocyte cel
• Protein Description: Critical for defining the anterior-posterior and dorsal-ventral axes of the egg. May signal directly to dorsal follicle cells through the receptor torpedo (top). During oogenesis this signaling pathway instructs follicle cells to follow a dorsal pathway of development rather than the default ventral pathway..
• Protein Sequence: MMQIPFTRIFKVIFVLSTIVAVTDCCSSRILLLREHTLKIVQHQHSHMHEHAHELQQQIQETAVELLNRLELQRKQLEASAQEEADQLHPDTDPNPDSGGQLPNADDSIAADPEQDGIILGSSTDTWLASESSTPITDSETVTTPETVTHTGEPPPDPSSSSTPDSTTPSPNDKETEIQMLPCSEAYNTSFCLNGGHCFQHPMVNNTVFHSCLCVNDYDGERCAYKSWNGDYIYSPPTAQRKVRMAHIVFSFPVLLMLSSLYVLFAAVFMLRNVPDYRRKQQQLHLHKQRFFVRC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
188	N-linked_Glycosylation	LPCSEAYNTSFCLNG EECCCCCCCCEECCC	35.97	-
205	N-linked_Glycosylation	CFQHPMVNNTVFHSC CCCCCCCCCCEEECC	32.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRK_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRK_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRK_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ROGDI_DROME	rogdi	physical	15710747
SIF2_DROME	sif	physical	15710747
SIF1_DROME	sif	physical	15710747
COPB_DROME	betaCOP	physical	15710747
FLNA_DROME	cher	physical	15710747
DYLT_DROME	Dlc90F	physical	15710747
PATJ_DROME	Patj	physical	15710747
PTPS_DROME	pr	physical	15710747
C1TC_DROME	pug	physical	15710747
SINA_DROME	sina	physical	15710747
HP1_DROME	Su(var)205	physical	15710747
MED1_DROME	MED1	physical	15710747
STAR_DROME	S	genetic	11782411
LIS1_DROME	Lis-1	genetic	10993674
CSN5_DROME	CSN5	genetic	12397113

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.