COPB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPB_DROME
• UniProt AC: P45437
• Protein Name: Coatomer subunit beta
• Gene Name: betaCOP {ECO:0000312|FlyBase:FBgn0008635}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 964
• Subcellular Localization: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic side o
• Protein Description: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets..
• Protein Sequence: MTSQVPCYTIINSPDLEVTNEMQLKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNHTIKKLLLIFWEIVPKTSADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPAIRACLDHRHSYVRRNAVLAIFTIYKNFDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQERALNYLASCIDQVHTFGDILQLVIVELIYKVCHANPAERSRFIRCIYNLLNSSSNAVRYESAGTLITLSLAPTAIKAAASCYIELVVKESDNNVKLIVLDRLVAMKEHEGMEKVMQDLVMDVLRVLAAPDIEVRRKTLALALDLVYSRNIGEMVLVLKKEVAKTHNVEHEDTGKYRQLLVRTLHTCSIKFPDVAANVIPVLVEFLSDTNELAAADVLIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWILGEYVEGSQILEVIAVIQQTLGEVPMVEAEQRRLAGDQTEEQKQQQGSAGGNAAGSAAEGSGSGNASNKVTSDGTYATQSAYSLAPVAKAEKRPPLRQYLMDGDFFIGAALSATLTKLALRYAELETEARAQNRLTTQVMLIMSSILHLGKSGFPSKPITNDDTDRIFVCLRTLSERTPEAISVFTLYCREALGKMLDAQHDEDQRMLKEKQKATAKVQPDDPVLFAQLSNGRDNQLGENVFESSLNQALAGSKNAQLSDVASPNSKLNKVTQLTGFSDPVYAEAYVNVNQYDIVLDVLIVNQTNDTLQNCTLELATLGDLKLVERPHPVVLAPHDFCNIKANVKVSSTENGIIFGNIVYETALNTNVVVLNTIHIDIMDYIIPASCTDTEFRQMWQDFEWENKVTVNTSFTDLHEYLKHLLKSTNMKCLTPEKALSGQCGFMAANMYAKSIFGENALANLSIEKPVDDPDSKVTGHIRIRAKSQGMALSLGDKISSSQKQSVQAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
541	Phosphorylation	YATQSAYSLAPVAKA EECCCCCCCCCCCCH	20.12	21082442
711	Phosphorylation	LNQALAGSKNAQLSD HHHHHHCCCCCCHHC	19.68	29892262
721	Phosphorylation	AQLSDVASPNSKLNK CCHHCCCCCCCHHCH	25.18	19429919
724	Phosphorylation	SDVASPNSKLNKVTQ HCCCCCCCHHCHHHH	41.74	19429919
867	Phosphorylation	ENKVTVNTSFTDLHE CCCEEEECCCHHHHH	22.38	19429919
868	Phosphorylation	NKVTVNTSFTDLHEY CCEEEECCCHHHHHH	22.42	19429919
877	Acetylation	TDLHEYLKHLLKSTN HHHHHHHHHHHHHCC	31.16	21791702
942	Phosphorylation	HIRIRAKSQGMALSL EEEEEECCCCCEEHH	30.86	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NFS1_DROME	CG12264	physical	22036573
TCPG_DROME	Cctgamma	physical	22036573
2AAA_DROME	Pp2A-29B	physical	22036573
CCD1P_DROME	Cyp12d1-p	physical	22036573
IDH3A_DROME	l(1)G0156	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.