2AAA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 2AAA_DROME
• UniProt AC: P36179
• Protein Name: Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit
• Gene Name: Pp2A-29B
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 591
• Protein Description: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit..
• Protein Sequence: MAASDKSVDDSLYPIAVLIDELKNEDVQLRLNSIKKLSTIALALGEERTRSELIPFLTETIYDEDEVLLALADQLGNFTSLVGGPEFAMYLIPPLESLATVEETVVRDKAVESLRTVAAEHSAQDLEIHVVPTLQRLVSGDWFTSRTSACGLFSVCYPRVTQPVKAELRANFRKLCQDETPMVRRAAANKLGEFAKVVETEYLKSDLIPNFVQLAQDDQDSVRLLAVEACVSIAQLLPQDDVEHLVLPTLRQCASDSSWRVRYMVAEKFVDLQKAVGPEITRVDLVPAFQYLLKDAEAEVRAAVATKVKDFCANLDKVNQVQIILSSILPYVRDLVSDPNPHVKSALASVIMGLSPMLGAYQTVEQLLPLFLIQLKDECPEVRLNIISNLDCVNDVIGIQQLSQSLLPAIVELAEDSKWRVRLAIIEYMPALAGQLGQEFFDQKLRGLCMGWLNDHVYAIREAATLNMKKLVEQFGAPWAEQAIIPMILVMSRNKNYLHRMTCLFCLNVLAEVCGTDITTKLLLPTVLLLAADPVANVRFNVAKTLQKISPFLEASVIDAQVKPTLDKLNTDTDVDVKHFAAQAIAGIAAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAASDKSVD ------CCCCCCCCC	18.70	-
7	Phosphorylation	-MAASDKSVDDSLYP -CCCCCCCCCCCHHH	35.45	19429919
139	Phosphorylation	PTLQRLVSGDWFTSR CCCHHHHCCCCHHCC	35.31	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 2AAA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 2AAA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 2AAA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN3_DROME	CSN3	physical	14605208
UBCD4_DROME	UbcD4	physical	14605208
AKT1_DROME	Akt1	physical	27626673

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.