IDH3A_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IDH3A_DROME
• UniProt AC: Q9VWH4
• Protein Name: Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
• Gene Name: l(1)G0156
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 377
• Subcellular Localization: Mitochondrion.
• Protein Sequence: MAARFIQKILNQLGLIAARDAPAVTATPAVSQVNATPAASRSYSSGTKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGRAKCSEFTNEICAKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	Acetylation	PVRGPDGKFGIPQAA CCCCCCCCCCCCHHH	48.04	21791702
93	Acetylation	PVRGPDGKFGIPQAA CCCCCCCCCCCCHHH	48.04	-
109	Ubiquitination	DSVNTNKIGLKGPLM HCCCCCCCCCCCCCC	9.42	31113955
132	Ubiquitination	SLNLALRKEFNLYAN HHHHHHHHHHCEECC	68.46	31113955
216	Acetylation	KKVTVVHKANIMRMS CEEEEEEHHHEEEEC	31.36	21791702
216	Acetylation	KKVTVVHKANIMRMS CEEEEEEHHHEEEEC	31.36	-
341	Acetylation	ELNTYADKIERAAFE HHHHHHHHHHHHHHH	37.99	21791702
341	Acetylation	ELNTYADKIERAAFE HHHHHHHHHHHHHHH	37.99	-
354	Acetylation	FETIKEGKYLTGDLG HHHHHCCCCCCCCCC	37.87	21791702
354	Acetylation	FETIKEGKYLTGDLG HHHHHCCCCCCCCCC	37.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IDH3A_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IDH3A_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IDH3A_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VND_DROME	vnd	physical	14605208
NFS1_DROME	CG12264	physical	22036573
ACADM_DROME	CG12262	physical	22036573
2AAA_DROME	Pp2A-29B	physical	22036573
KRH2_DROME	Kr-h2	physical	22036573
YC17_DROME	CG16817	physical	22036573
CCD1P_DROME	Cyp12d1-p	physical	22036573
TERA_DROME	TER94	physical	22036573
SPTCA_DROME	alpha-Spec	physical	22036573
NACA_DROME	Nacalpha	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.