PTPS_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTPS_DROME
• UniProt AC: P48611
• Protein Name: 6-pyruvoyl tetrahydrobiopterin synthase
• Gene Name: pr
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 168
• Protein Description: Required for pigment and biopterin synthesis..
• Protein Sequence: MSQQPVAFLTRRETFSACHRLHSPQLSDAENLEVFGKCNNFHGHGHNYTVEITVRGPIDRRTGMVLNITELKEAIETVIMKRLDHKNLDKDVEYFANTPSTTENLAVYIWDNIRLQLKKPELLYEVKIHETPKNIISYRGPYPLNGIYNPINKRIAHDSCTNISSDSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	AFLTRRETFSACHRL EEHHHHHHHHHHHHC	22.52	22817900
23	Phosphorylation	SACHRLHSPQLSDAE HHHHHCCCCCCCCHH	20.95	19429919
81	Ubiquitination	AIETVIMKRLDHKNL HHHHHHHHCCCCCCC	38.39	31113955
148	Phosphorylation	PYPLNGIYNPINKRI CCCCCCCCCCCCCCC	19.11	18281928
159	Phosphorylation	NKRIAHDSCTNISSD CCCCCCHHCCCCCCC	16.99	22817900
161	Phosphorylation	RIAHDSCTNISSDSD CCCCHHCCCCCCCCC	39.27	22817900
164	Phosphorylation	HDSCTNISSDSD--- CHHCCCCCCCCC---	30.11	19429919
165	Phosphorylation	DSCTNISSDSD---- HHCCCCCCCCC----	37.02	19429919
167	Phosphorylation	CTNISSDSD------ CCCCCCCCC------	47.36	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTPS_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTPS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTPS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTPS_DROME	pr	physical	14605208
TPIS_DROME	Tpi	physical	22036573
AN32A_DROME	Mapmodulin	physical	22036573
SUS_DROME	su(s)	genetic	8846895
WHITE_DROME	w	genetic	11962627

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-159; THR-161; SER-164;SER-165 AND SER-167, AND MASS SPECTROMETRY.
PubMed: 18327897