SUS_DROME - dbPTM
SUS_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SUS_DROME
UniProt AC P22293
Protein Name Protein suppressor of sable {ECO:0000303|PubMed:1703632}
Gene Name su(sable) {ECO:0000312|FlyBase:FBgn0003575}
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1325
Subcellular Localization Nucleus . Distributed in a reticulated pattern in embryo and salivary gland.
Protein Description Affects the transcript levels of those alleles that it suppresses. May be involved in influencing complex assembly on cryptic 5'-splice sites or nuclear RNA export; binds RNA preferentially at a sequence that resembles a cryptic 5'-splice site (in vitro)..
Protein Sequence MSVALADEPLIDLEEDLEDGEIDDDEEDEQQSSKIQVQKKTFVGDDDVQFVGVEAKNQNDDEDVVYVGPSTDAVCLQNSNSTKSKKPRPLEDDHASSIELAIANALKKKGIEPPMPRMRSSNQDTSDQSLEGSGEGLATANPLLQSTRSSRRRKRKKEREREQKKDKEQQNRSRRDENDVSVVPGGVEDMDEYEMMNVRGGSPPPGGAAPPLSSCGQRFSGADWDMDDGSAATGAAGLGAGGGGGYNSHSSYDSYSDEETNGPGLMNQRRRTRRDNEKEHQRGVNNRKRRDRDRLEGGLAGSGSKRNRRDSGEGGGGGQEKMGGSNRVEPRKLELCKFYLMDCCAKRDKCSYMHKEFPCKYYYLGMDCYAGDDCLFYHGEPLSEQLRNVLLKHMETAPKEILGDFKRISRDIAIVQMTRRHEQLCDQLNRENTWNSIGCGLMGKRQDHQMQQQQQQLQHQQLQQQQEQQQTQQQAAADGGGCIPSLLDMVINPPLSENKRKSRWTEKMGAKAAAGAAGSSERDSTSPDAKPLPPHLDLANLSHVLSAENMAKLNKLGITNLEQMLQVPFGQLTEAGLTLVEIGEIQRKAEDAKPQTQAELESSTPPSKRETEANNSNSKSNGLIMVDYTQYLKDAHVSFSGNDPLDDDRDDDEQLIIDDGNDSTAEEDQQPKKAKAPPAATHESSTEEAPLPSVFDLPSFMNNMLGQGSSARQLLPASATSPNQENAHLPGGDQSTHKSAPIGGGTSTNVLGRILFGDKQSDPEARAAFYRDIIRNPFKAHSGDGDVDSSNENSNSNSHSLTPTPTPEPGSQSPKPEDHDQDMPELPVIAPALPPTTPSLYVRRSMYDFDPVKEQEHGRQELLTEEKEQYQRDTDMRLPFEPMKHYMPATEIDAAIFSHTPIRWQLHEVTIEESSYAQIRASALHKEQRELRDPRMRRILGLPETPDNSGPLGSVPIMGPSSFSVDNIARCATTIASPDLETAVRDSTPSSPPPSVVNLPSMSVPPPSMRVPPPNIQVEKPTVRTDPRRDPRRAVLQAPTKGASTANTTAPNASGGSKQISEIRSLLQVSNWYNNLGTNNKIMVNQQLALVFTELKKFHQLPNDAPKIFDVSFIVNNTTLQQIFAKLFIFVDDNGEVVQIPEEPNGNGAALGGGGDSGGGVGGGGGGGGVVLPNLSQPPPNLSQMLRLPPPNIRMLRMSGMMMQMGNVGPPFNQPPPRGGLMGMPPNGNGLNQGVGNLGGLGQLGINQGGGPVPNGNPFNPFGGNNGGGAGVMNNMNSMGNMGMGFNNFNNNGGRGGHFPGGGSGGNGNGNNRNQRGGNHRNRNI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
120PhosphorylationPPMPRMRSSNQDTSD
CCCCCCCCCCCCCCC		25.0519429919
121PhosphorylationPMPRMRSSNQDTSDQ
CCCCCCCCCCCCCCC		28.3119429919
125PhosphorylationMRSSNQDTSDQSLEG
CCCCCCCCCCCCCCC		25.1619429919
126PhosphorylationRSSNQDTSDQSLEGS
CCCCCCCCCCCCCCC		41.7819429919
129PhosphorylationNQDTSDQSLEGSGEG
CCCCCCCCCCCCCCC		33.1219429919
133PhosphorylationSDQSLEGSGEGLATA
CCCCCCCCCCCCHHH		25.0519429919
202PhosphorylationMMNVRGGSPPPGGAA
EEECCCCCCCCCCCC		36.7425749252
311PhosphorylationSKRNRRDSGEGGGGG
CCCCCCCCCCCCCCC		36.6119429919
519PhosphorylationAAAGAAGSSERDSTS
HHHHHCCCCCCCCCC		25.0519429919
520PhosphorylationAAGAAGSSERDSTSP
HHHHCCCCCCCCCCC		35.4219429919
524PhosphorylationAGSSERDSTSPDAKP
CCCCCCCCCCCCCCC		36.6919429919
525PhosphorylationGSSERDSTSPDAKPL
CCCCCCCCCCCCCCC		48.8719429919
526PhosphorylationSSERDSTSPDAKPLP
CCCCCCCCCCCCCCC		25.4119429919
602PhosphorylationQTQAELESSTPPSKR
CHHHHHHHCCCCHHH		52.7319429919
603PhosphorylationTQAELESSTPPSKRE
HHHHHHHCCCCHHHC		35.2419429919
604PhosphorylationQAELESSTPPSKRET
HHHHHHCCCCHHHCC		48.8019429919
607PhosphorylationLESSTPPSKRETEAN
HHHCCCCHHHCCCCC		45.6119429919
663PhosphorylationIIDDGNDSTAEEDQQ
EECCCCCCCHHHHHC		33.2529892262
664PhosphorylationIDDGNDSTAEEDQQP
ECCCCCCCHHHHHCC		40.7422668510
718PhosphorylationARQLLPASATSPNQE
HHHHCCCCCCCCCCC		30.0919429919
720PhosphorylationQLLPASATSPNQENA
HHCCCCCCCCCCCCC		42.0719429919
721PhosphorylationLLPASATSPNQENAH
HCCCCCCCCCCCCCC		22.9019429919
898PhosphorylationEIDAAIFSHTPIRWQ
CCCEEHHCCCCCCEE		21.9719429919
900PhosphorylationDAAIFSHTPIRWQLH
CEEHHCCCCCCEEEE		21.1519429919
977PhosphorylationRCATTIASPDLETAV
HHHHEECCCCHHHHH		18.3325749252
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SUS_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SUS_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SUS_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RS3_DROMERpS3physical
14605208
STAR_DROMESgenetic
2503417
WDR82_DROMEWdr82physical
26577379
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SUS_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-524; THR-604; SER-663AND THR-664, AND MASS SPECTROMETRY.

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