dbPTM

PATJ_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PATJ_DROME
UniProt AC	Q9NB04
Protein Name	Patj homolog
Gene Name	Patj
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	871
Subcellular Localization	Membrane . Membrane-associated. Localizes to the subapical domain of cells. Sdt is required for its localization. At mitotic cycles 13 and 14, during cellularization, it localizes at the leading edge of the invaginating membranes. It is then exclusiv
Protein Description	Involved in cell polarity establishment. Probably participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex..
Protein Sequence	MHLSADISSALQQIEAVKKGIDESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSELNAQLAQHPSMLPNDFDIDVAGNLVLSLNGGEVMYDFDEQRSSSHSHSAPGSPDKSGGVGEEPRPQSQNSKGAGVADLYATDYAQIQAIELVNDGTGLGFGIIGARNSGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSGTHVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTTTEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDANGLGITIAGYVCEKEELSGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQLQQAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTPSRSITRELEEEALPAPEAFMTTPPSVTTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEVVPLADKTEAKNSGVITRHKYYTDPELSDDAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGISLEGTVDVEGGREVRPHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLPFSDDTLKKLSNNFENLLPATDRLVKAKSDGSLATAGSVADGDSVAAAAASFSKLKSRSLEPLTGLAMWSSQPQIIELVKGDRGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGDRLLFVNSINLENASLDQAVQALKGASKGVVRIGVAKPLPMTDNSLKACSNASTTSEETLDAQPSPPALPTVAPPAMPPSASMGAEPDLIPDWRN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
103	Phosphorylation	YDFDEQRSSSHSHSA EECCCCCCCCCCCCC	35.57	19429919
104	Phosphorylation	DFDEQRSSSHSHSAP ECCCCCCCCCCCCCC	33.97	19429919
105	Phosphorylation	FDEQRSSSHSHSAPG CCCCCCCCCCCCCCC	30.20	19429919
107	Phosphorylation	EQRSSSHSHSAPGSP CCCCCCCCCCCCCCC	22.53	19429919
109	Phosphorylation	RSSSHSHSAPGSPDK CCCCCCCCCCCCCCC	38.89	19429919
113	Phosphorylation	HSHSAPGSPDKSGGV CCCCCCCCCCCCCCC	28.94	19429919
128	Phosphorylation	GEEPRPQSQNSKGAG CCCCCCCCCCCCCCC	33.73	19429919
131	Phosphorylation	PRPQSQNSKGAGVAD CCCCCCCCCCCCHHH	25.48	27794539
497	Phosphorylation	QLVAVRDSLDGSTKI EEEEEEECCCCCCEE	20.14	27794539
536	Phosphorylation	YYTDPELSDDAETEI EECCHHHCCCHHHHH	31.61	27794539
664	Phosphorylation	DDTLKKLSNNFENLL HHHHHHHHHHHHHHC	38.31	22817900
682	Phosphorylation	DRLVKAKSDGSLATA HHHHHCCCCCCCCCC	52.65	18327897
685	Phosphorylation	VKAKSDGSLATAGSV HHCCCCCCCCCCCCC	21.59	27794539
697	Phosphorylation	GSVADGDSVAAAAAS CCCCCHHHHHHHHHH	21.13	27794539
710	Phosphorylation	ASFSKLKSRSLEPLT HHHHHHHHCCCCCCC	37.22	27794539
712	Phosphorylation	FSKLKSRSLEPLTGL HHHHHHCCCCCCCCC	44.14	21082442
724	Phosphorylation	TGLAMWSSQPQIIEL CCCHHHCCCCCEEHH	30.30	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PATJ_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PATJ_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PATJ_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRB_DROME	crb	physical	11076972
SQH_DROME	sqh	genetic	23128243
CADE_DROME	shg	genetic	23128243
CRB_DROME	crb	genetic	23136386
SQH_DROME	sqh	physical	23128243
MOEH_DROME	Moe	physical	12213838
MYSN_DROME	zip	physical	23128243
NRX4_DROME	Nrx-IV	physical	10102271
CRB_DROME	crb	physical	11850625
CRB_DROME	crb	physical	12213838
CRB_DROME	crb	physical	22105348
PATJ_DROME	Patj	physical	10102271
APKC_DROME	aPKC	physical	15302858

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PATJ_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-682, AND MASSSPECTROMETRY.	18327897 [Abstract]