MYSN_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYSN_DROME
• UniProt AC: Q99323
• Protein Name: Myosin heavy chain, non-muscle
• Gene Name: zip
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2057
• Subcellular Localization: Cell projection, cilium . Expression in neurons and scolopale cells is increased at the apical tips of cilia.
• Protein Description: Nonmuscle myosin appears to be responsible for cellularization. Required for morphogenesis and cytokinesis. [PubMed: 24786584 Necessary for auditory transduction: plays a role in Johnston's organ organization by acting in scolopidial apical attachment]
• Protein Sequence: MKSAWLALKSKSALHPKSEYPVSNIHYPKAANYRQTRNYLEIAAKMSEEVDRNDPELKYLSVERNQFNPIRPRRPSGHRSVLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATITELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEADGKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRTGGIGLSSSRLTGTPSSKRAGGGGGSDDSSVQDESLDGEDSAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 4)	Phosphorylation	-	61.25	27794539
2 (in isoform 2)	Phosphorylation	-	61.25	27794539
58	Acetylation	DRNDPELKYLSVERN HCCCCCHHEEEEECC	42.35	19608861
61	Phosphorylation	DPELKYLSVERNQFN CCCHHEEEEECCCCC	20.88	25749252
125	Acetylation	ILRDDIQKMNPPKFD EECHHHHHHCCCCCC	40.76	19608861
336	Acetylation	DNSSRFGKFIRINFD CCCCCCEEEEEEEEC	34.60	19608861
742	Acetylation	RTVSHLYKEQLAKLM HHHHHHHHHHHHHHH	45.40	19608861
1229	Phosphorylation	EKVRRDLSEELEALK HHHHHHHHHHHHHHH	33.06	19429919
1286	Phosphorylation	ADMRHKHSQELNSIN HHHHHHHHHHHHHHH	30.10	19429919
1291	Phosphorylation	KHSQELNSINDQLEN HHHHHHHHHHHHHHH	35.08	19429919
1326	Phosphorylation	DLATELRSVNSSRQE HHHHHHHHHCCHHHH	37.97	25749252
1680	Acetylation	EKRRGLVKQLRDLET HHHHHHHHHHHHHHH	48.97	-
2007	Phosphorylation	AMNREINSLKTKLRR HHHHHHHHHHHHHHH	36.58	25749252
2015	Phosphorylation	LKTKLRRTGGIGLSS HHHHHHHCCCCCCCC	33.07	19429919
2021	Phosphorylation	RTGGIGLSSSRLTGT HCCCCCCCCCCCCCC	22.51	22817900
2022	Phosphorylation	TGGIGLSSSRLTGTP CCCCCCCCCCCCCCC	25.23	27331610
2026	Phosphorylation	GLSSSRLTGTPSSKR CCCCCCCCCCCCCCC	37.59	25749252
2028	Phosphorylation	SSSRLTGTPSSKRAG CCCCCCCCCCCCCCC	18.11	29892262
2030	Phosphorylation	SRLTGTPSSKRAGGG CCCCCCCCCCCCCCC	48.61	21082442
2031	Phosphorylation	RLTGTPSSKRAGGGG CCCCCCCCCCCCCCC	27.62	21082442
2049	Phosphorylation	DSSVQDESLDGEDSA CCCCCCCCCCCCCCC	39.80	22817900
2055	Phosphorylation	ESLDGEDSAN----- CCCCCCCCCC-----	25.96	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2021	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
2021	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
2022	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
2022	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYSN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYSN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRYA_DROME	Sry-alpha	physical	14605208
EFHD2_DROME	Swip-1	physical	22036573
DNAT_DROME	Dat	physical	22036573
CP2B_DROME	Capa	physical	22036573
EOGT_DROME	Eogt	physical	22036573
PROF_DROME	chic	genetic	20553709
MYO7A_DROME	ck	genetic	20599890
FRIZ_DROME	fz	genetic	20599890
APKC_DROME	aPKC	genetic	20392741
MLC2_DROME	Mlc-c	physical	16917818
SQH_DROME	sqh	physical	16917818
L2GL_DROME	l(2)gl	physical	15694314
MYSN_DROME	zip	physical	17901043
MYSN_DROME	zip	physical	17989074

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2021 AND SER-2022, ANDMASS SPECTROMETRY.
PubMed: 18327897