APKC_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APKC_DROME
• UniProt AC: A1Z9X0
• Protein Name: Atypical protein kinase C {ECO:0000312|EMBL:AAF58177.2}
• Gene Name: aPKC {ECO:0000312|EMBL:AAF58177.2, ECO:0000312|FlyBase:FBgn0261854}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 606
• Subcellular Localization: Cytoplasm, cell cortex . Apicolateral cell membrane ; Peripheral membrane protein . Cytoplasmic at interphase but localizes to the apical cell cortex during mitosis.
• Protein Description: Serine/threonine protein kinase which is required for apico-basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishment of correct oocyte polarity. Essential for apical localization of l(2)gl and par-6 in neuroblasts and for exclusion of mira from the apical cortex. Phosphorylates baz which is required for targeting of baz to the postsynaptic region where it is involved in actin organization, and for apical exclusion of baz which is necessary for establishment of the apical/lateral border in epithelial cells. Phosphorylates yrt which prevents its premature apical localization and is necessary for correct epithelial cell polarization. Required for the establishment of mitotic spindle orientation during symmetric division of epithelial cells and for apical exclusion of raps/Pins. Involved in symmetric adherens junction positioning during embryogenesis. Required for polarization of the spermatid cyst which is necessary for sperm differentiation. Required for stimulation of the Toll signaling pathway which activates Dif and dl and plays a role in innate immunity. Plays a role in memory enhancement..
• Protein Sequence: MQKMPSQILNDGSSVSLNSASMNMANTPNSITVKTAYNGQIIITTINKNISYEELCYEIRNICRFPLDQPFTIKWVDEENDPCTISTKMELDEAIRLYEMNFDSQLVIHVFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHCTDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDHAHIVAPPPPEDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
419	Phosphorylation	EGIRPGDTTSTFCGT CCCCCCCCCCCCCCC		23607784
420	Phosphorylation	GIRPGDTTSTFCGTP CCCCCCCCCCCCCCC		23607784
421	Phosphorylation	IRPGDTTSTFCGTPN CCCCCCCCCCCCCCC		23607784
422	Phosphorylation	RPGDTTSTFCGTPNY CCCCCCCCCCCCCCC		23607784

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APKC_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APKC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APKC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAP60_DROME	Bap60	physical	14605208
DTBP1_DROME	Dysb	physical	14605208
ARM_DROME	arm	genetic	21483653
L2GL_DROME	l(2)gl	genetic	16357871
NUMB_DROME	numb	genetic	18854163
NUMB_DROME	numb	genetic	22394487
DYHC_DROME	Dhc64C	genetic	26455305
ORB2_DROME	orb2	genetic	24830287
PP2A_DROME	mts	genetic	19690050
L2GL_DROME	l(2)gl	physical	27089924
L2GL_DROME	l(2)gl	physical	23835532
CLU_DROME	clu	physical	23835532
CRB_DROME	crb	physical	15302858
PATJ_DROME	Patj	physical	15302858
PP2A_DROME	mts	physical	19374896
VHL_DROME	Vhl	physical	20388653

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.