VHL_DROME - dbPTM
VHL_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VHL_DROME
UniProt AC Q9V3C1
Protein Name Protein Vhl
Gene Name Vhl {ECO:0000312|FlyBase:FBgn0041174}
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 178
Subcellular Localization
Protein Description Involved in development of tracheal vasculature. Probably involved in halting cell migration at the end of vascular tube outgrowth. Possesses E3 ubiquitin ligase activity when in complex with Elongin BC complex, Cul2 and Rox1a/Rbx1, and can target sima/Hif1a for ubiquitination. May play a critical role in promoting microtubule stabilization when tubulins are correctly folded by the prefoldin complex. If tubulin is incorrectly folded, may promote its degradation..
Protein Sequence MALQIAQNNRDGQQLVGADQGKVEVYVLFANTTYRTLDLYWVCERERENMYLTLKPFEEVRVNTFTTHSWLFRDYYTGERMHVRSQRIFQPIRVRVPKSQQSPDQLVDVRSEVLIHFPMRSLRENCLWLVARWLIRTSNAPRRIIHGYHIPSTLKQQLLSLLTCIESYSRVAGTRRRR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
102PhosphorylationRVPKSQQSPDQLVDV
ECCCCCCCCCCEEEC
23.8622817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VHL_DROME !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VHL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VHL_DROME !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRC8_DROMETrc8physical
12032852
FBXW7_DROMEagogenetic
19285057
FBXW7_DROMEagogenetic
23459416
FGFR2_DROMEbtlgenetic
19285057
SIMA_DROMEsimagenetic
19285057
TBB1_DROMEbetaTub56Dphysical
22451918
PFD3_DROMEmgrphysical
22451918
NDKA_DROMEawdphysical
20516215
NDKA_DROMEawdphysical
24915993
VHL_DROMEVhlphysical
22451918

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VHL_DROME

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Related Literatures of Post-Translational Modification

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