dbPTM

NDKA_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NDKA_DROME
UniProt AC	P08879
Protein Name	Nucleoside diphosphate kinase
Gene Name	awd
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	153
Subcellular Localization	Cytoplasm . Cytoplasm, cytoskeleton . Microtubule-associated.
Protein Description	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate..
Protein Sequence	MAANKERTFIMVKPDGVQRGLVGKIIERFEQKGFKLVALKFTWASKELLEKHYADLSARPFFPGLVNYMNSGPVVPMVWEGLNVVKTGRQMLGATNPADSLPGTIRGDFCIQVGRNIIHGSDAVESAEKEIALWFNEKELVTWTPAAKDWIYE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAANKERTF ------CCCCCCCEE	21.53	12099695
13	Acetylation	ERTFIMVKPDGVQRG CCEEEEECCCCCCCH	21.73	21791702
24	Acetylation	VQRGLVGKIIERFEQ CCCHHHHHHHHHHHH	32.79	21791702
35	Acetylation	RFEQKGFKLVALKFT HHHHCCCEEEEEECH	51.20	21791702
45	Phosphorylation	ALKFTWASKELLEKH EEECHHHCHHHHHHH	20.44	19429919
46	Acetylation	LKFTWASKELLEKHY EECHHHCHHHHHHHC	44.63	21791702
51	Acetylation	ASKELLEKHYADLSA HCHHHHHHHCCCCCC	41.71	21791702
95	Phosphorylation	GRQMLGATNPADSLP HHHCCCCCCCHHCCC	39.68	21082442
121	Phosphorylation	GRNIIHGSDAVESAE CCCEECCCHHHHHHH	14.29	19429919
126	Phosphorylation	HGSDAVESAEKEIAL CCCHHHHHHHHHHHH	34.82	7559441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NDKA_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NDKA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NDKA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SH3BG_DROME	Sh3beta	physical	22036573
NLP_DROME	Nlp	physical	22036573
PDI_DROME	Pdi	physical	22036573
FKB12_DROME	FK506-bp2	physical	22036573
CALR_DROME	Crc	physical	22036573
ENO_DROME	Eno	physical	22036573
THIO2_DROME	Trx-2	physical	22036573
SODC_DROME	Sod	physical	22036573
PPIA_DROME	Cyp1	physical	22036573
NACA_DROME	Nacalpha	physical	22036573
INO1_DROME	Inos	physical	22036573
ATPB_DROME	ATPsyn-beta	physical	22036573
YC17_DROME	CG16817	physical	22036573
DOD_DROME	dod	physical	22036573
TCTP_DROME	Tctp	physical	22036573
MOEH_DROME	Moe	physical	22036573
1433E_DROME	14-3-3epsilon	physical	22036573
PROF_DROME	chic	physical	22036573
TRXR1_DROME	Trxr-1	physical	22036573
IF5A_DROME	eIF-5A	physical	22036573
HCD2_DROME	scu	physical	22036573
MYSN_DROME	zip	physical	22036573
6PGD_DROME	Pgd	physical	22036573
EF2_DROME	EF2	physical	22036573
UCHL_DROME	Uch	physical	22036573
PCNA_DROME	PCNA	physical	22036573
PSA71_DROME	Prosalpha4	physical	22036573
JUPIT_DROME	Jupiter	physical	22036573
PSA6_DROME	Prosalpha1	physical	22036573
HMGD_DROME	HmgD	physical	22036573
CALM_DROME	Cam	physical	22036573
ITPA_DROME	CG8891	physical	22036573
ATP5J_DROME	ATPsyn-Cf6	physical	22036573
CH60_DROME	Hsp60	physical	22036573
EF1D_DROME	eEF1delta	physical	22036573
MIP_DROME	Mip	physical	22036573
RS21_DROME	RpS21	physical	22036573
TERA_DROME	TER94	physical	22036573
1433Z_DROME	14-3-3zeta	physical	22036573
PGK_DROME	Pgk	physical	22036573
GCH1_DROME	Pu	genetic	17585895
FGFR2_DROME	btl	genetic	14630942
CSUP_DROME	Catsup	genetic	17585895
CISY_DROME	kdn	physical	22036573
VHL_DROME	Vhl	physical	20516215
VHL_DROME	Vhl	physical	24915993

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NDKA_DROME

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Post-translational processing of Drosophila nucleoside diphosphatekinase."; Stenberg L.M., Stenflo J., Holmgren P., Brown M.A.; Biochem. Biophys. Res. Commun. 295:689-694(2002). Cited for: PROTEIN SEQUENCE OF 3-15; 33-35; 47-96 AND 147-153, MASS SPECTROMETRY,BLOCKAGE OF N-TERMINUS, AND ACETYLATION AT ALA-2.	12099695 [Abstract]
Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126, AND MASSSPECTROMETRY.	18327897 [Abstract]