CALM_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CALM_DROME
• UniProt AC: P62152
• Protein Name: Calmodulin
• Gene Name: Cam
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 149
• Protein Description: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases..
• Protein Sequence: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVTMMTSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADQLTEEQ ------CCCCCCHHH	17.16	-
22	Acetylation	EAFSLFDKDGDGTIT HHHHCCCCCCCCCEE	57.17	21791702
31	Acetylation	GDGTITTKELGTVMR CCCCEEHHHHHHHHH	42.14	21791702
80	Phosphorylation	MARKMKDTDSEEEIR HHHHCCCCCCHHHHH	35.59	19429919
82	Phosphorylation	RKMKDTDSEEEIREA HHCCCCCCHHHHHHH	49.34	19429919
95	"N6,N6,N6-trimethyllysine"	EAFRVFDKDGNGFIS HHHHHHCCCCCCEEC	56.95	-
95	Acetylation	EAFRVFDKDGNGFIS HHHHHHCCCCCCEEC	56.95	21791702
95	Methylation	EAFRVFDKDGNGFIS HHHHHHCCCCCCEEC	56.95	17610210
111	Phosphorylation	AELRHVMTNLGEKLT HHHHHHHHHHHCCCC	26.63	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CALM_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CALM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CALM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
Y9705_DROME	CG9705	physical	14605208
RDGC_DROME	rdgC	physical	11754840
EFHD2_DROME	Swip-1	physical	22036573
ATG5_DROME	Atg5	physical	22036573
CAC1D_DROME	Ca-alpha1D	genetic	14668380
RYR_DROME	RyR	genetic	14668380
TIM_DROME	tim	physical	26590423
NINAC_DROME	ninaC	physical	8235618
NINAC_DROME	ninaC	physical	9813038
TRPL_DROME	trpl	physical	1314616
TRPL_DROME	trpl	physical	9813038
INAD_DROME	inaD	physical	9010208
MYS9_DROME	jar	physical	22851764
MYS9_DROME	jar	physical	16790438
TRP_DROME	trp	physical	9010208
KCC2A_DROME	CaMKII	physical	9813038
POE_DROME	poe	physical	9813038
RYR_DROME	RyR	physical	15557269
PP2B3_DROME	CanA-14F	physical	9813038

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Methylation

"Novel eye-specific calmodulin methylation characterized by proteinmapping in Drosophila melanogaster.";
Takemori N., Komori N., Thompson J.N. Jr., Yamamoto M.T.,Matsumoto H.;
Proteomics 7:2651-2658(2007).
Cited for: METHYLATION AT LYS-95.
PubMed: 17610210