NINAC_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NINAC_DROME
• UniProt AC: P10676
• Protein Name: Neither inactivation nor afterpotential protein C
• Gene Name: ninaC
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1501
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton. Nucleus . Membrane . Localizes in the cytoplasm or punctate structures within the nuclei in the absence of rtp. Co-localizes with rtp in the rhabdomere membrane.
• Protein Description: Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities. [PubMed: 2449973 Essential for the expression and stability of the rtp protein in the photoreceptors]
• Protein Sequence: MMYLPYAQLPDPTDKFEIYEEIAQGVNAKVFRAKELDNDRIVALKIQHYDEEHQVSIEEEYRTLRDYCDHPNLPEFYGVYKLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAYIIRETCRAAIELNRNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEVVSAMESREPDITVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQQINDFISESLEKNAENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKMYPEDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQDLIMDRVSEKHSQFVKKHTATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLFLRLKMEGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFAKKWREKSIFQVLLHYRAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPFERINMREVNSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQLLTQHMEDDEPWDSPLQRNPSMTSCALTYNAYKKEQACQTNWDRMGESDNIYNQGYFRDPQQLRRNQMQMNMNAYNNAYNSYNSNYNNQNWGVHRSGSRRNSLKGYAAPPPPPPPMPSSNYYRNNPNQQQRNYQQRSSYPPSDPVRELQNMARNEGDNSEDPPFNFKAMLRKTNYPRGSETNTYDFNNRRGSDSGDQHTFQPPKLRSTGRRYQDDEGYNSSSGNYGVSRKFGQQQRAPTLRQSPASVGRSFEDSNARSFEEAGSYVEEEIAPGITLSGYAVDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
172	Phosphorylation	GLSRQVDSTLGKRGT CCCHHCCCCCCCCCE	27.03	27794539
173	Phosphorylation	LSRQVDSTLGKRGTC CCHHCCCCCCCCCEE	34.76	27794539
183	Phosphorylation	KRGTCIGSPCWMAPE CCCEECCCCCCCCHH	9.29	2449973
1410	Phosphorylation	DFNNRRGSDSGDQHT CCCCCCCCCCCCCCC	27.13	28490779
1412	Phosphorylation	NNRRGSDSGDQHTFQ CCCCCCCCCCCCCCC	46.06	28490779
1417	Phosphorylation	SDSGDQHTFQPPKLR CCCCCCCCCCCCCCC	20.52	28490779

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NINAC_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NINAC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NINAC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OPS3_DROME	Rh3	genetic	18786361
CALM_DROME	Cam	physical	8235618
INAD_DROME	inaD	physical	23536301

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183, AND MASSSPECTROMETRY.
PubMed: 18327897