| UniProt ID | TRP_DROME | |
|---|---|---|
| UniProt AC | P19334 | |
| Protein Name | Transient receptor potential protein | |
| Gene Name | trp | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1275 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Localized on plasma membrane loops found at the base of the rhabdomere, in close proximity to the calcium stores. |
|
| Protein Description | A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development.. | |
| Protein Sequence | MGSNTESDAEKALGSRLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYSWEAVDRSKSTFTVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFNHEPSHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFELLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYISNMFYVTWILCRATAWVIVHRDLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMKMLRKTLGRKRPSRTKSFMRKSMERAQTLHDKVMKLLVRRYITAEQRRRDDYGITEDDIIEVRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFVENLKQEMSESESGRDIFSSLAKVIGRKKTQKGDKDWNAIARKNTFASDPIGSKRSSMQRHSQRSLRRKIIEQANEGLQMNQTQLIEFNPNLGDVTRATRVAYVKFMRKKMAADEVSLADDEGAPNGEGEKKPLDASGSKKSITSGGTGGGASMLAAAALRASVKNVDEKSGADGKPGTMGKPTDDKKAGDDKDKQQPPKDSKPSAGGPKPGDQKPTPGAGAPKPQAAGTISKPGESQKKDAPAPPTKPGDTKPAAPKPGESAKPEAAAKKEESSKTEASKPAATNGAAKSAAPSAPSDAKPDSKLKPGAAGAPEATKATNGASKPDEKKSGPEEPKKAAGDSKPGDDAKDKDKKPGDDKDKKPGDDKDKKPADNNDKKPADDKDKKPGDDKDKKPGDDKDKKPSDDKDKKPADDKDKKPAAAPLKPAIKVGQSSAAAGGERGKSTVTGRMISGWL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 726 | Phosphorylation | TKSFMRKSMERAQTL CHHHHHHHHHHHHHH | 18.60 | 27794539 | |
| 828 | Phosphorylation | ENLKQEMSESESGRD HHHHHHHCCCHHHHH | 36.90 | 27794539 | |
| 830 | Phosphorylation | LKQEMSESESGRDIF HHHHHCCCHHHHHHH | 29.74 | 27794539 | |
| 832 | Phosphorylation | QEMSESESGRDIFSS HHHCCCHHHHHHHHH | 48.70 | 27794539 | |
| 864 | Phosphorylation | NAIARKNTFASDPIG HHHHHHCCCCCCCCC | 24.50 | 27794539 | |
| 867 | Phosphorylation | ARKNTFASDPIGSKR HHHCCCCCCCCCCCH | 39.46 | 27794539 | |
| 872 | Phosphorylation | FASDPIGSKRSSMQR CCCCCCCCCHHHHHH | 26.14 | 27794539 | |
| 936 | Phosphorylation | KMAADEVSLADDEGA HHCCCCCCCCCCCCC | 18.78 | 27794539 | |
| 958 | Phosphorylation | KPLDASGSKKSITSG CCCCCCCCCCCCCCC | 34.12 | 27794539 | |
| 961 | Phosphorylation | DASGSKKSITSGGTG CCCCCCCCCCCCCCC | 34.53 | 27794539 | |
| 963 | Phosphorylation | SGSKKSITSGGTGGG CCCCCCCCCCCCCHH | 28.54 | 27794539 | |
| 964 | Phosphorylation | GSKKSITSGGTGGGA CCCCCCCCCCCCHHH | 33.29 | 27794539 | |
| 967 | Phosphorylation | KSITSGGTGGGASML CCCCCCCCCHHHHHH | 35.86 | 27794539 | |
| 982 | Phosphorylation | AAAALRASVKNVDEK HHHHHHHHCCCCCCC | 27.47 | 27794539 | |
| 1123 | Phosphorylation | PSDAKPDSKLKPGAA CCCCCCCCCCCCCCC | 48.71 | 27794539 | |
| 1254 | Phosphorylation | AIKVGQSSAAAGGER CEEECCCCCCCCCCC | 17.65 | 27794539 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TRP_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRP_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRP_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TERA_DROME | TER94 | genetic | 27054334 | |
| LETM1_DROME | Letm1 | genetic | 27054334 | |
| ARRB_DROME | Arr2 | genetic | 16301334 | |
| ATC1_DROME | Ca-P60A | genetic | 27054334 | |
| PIPA_DROME | norpA | physical | 10644758 | |
| PIPA_DROME | norpA | physical | 18036153 | |
| GNAQ_DROME | Galphaq | physical | 10644758 | |
| KPC2_DROME | inaC | physical | 10644758 | |
| KPC2_DROME | inaC | physical | 18036153 | |
| INAD_DROME | inaD | physical | 10644758 | |
| INAD_DROME | inaD | physical | 10995445 | |
| INAD_DROME | inaD | physical | 18036153 | |
| INAD_DROME | inaD | physical | 23687378 | |
| INAD_DROME | inaD | physical | 26456832 | |
| INAD_DROME | inaD | physical | 26853938 | |
| INAD_DROME | inaD | physical | 8630257 | |
| TRP_DROME | trp | physical | 23687378 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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