dbPTM

ATC1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATC1_DROME
UniProt AC	P22700
Protein Name	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
Gene Name	Ca-P60A
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1020
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein . Sarcoplasmic reticulum membrane Multi-pass membrane protein . Colocalizes with SclA and SclB at the sarcoplasmic reticulum (SR) and the dyad, a structure in which the SR membrane lies c
Protein Description	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium..
Protein Sequence	MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEMLNAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSIPVVLLDETLKFVARKIADGESPIYKMHGIVLMWAVFFGLLYAMML

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Acetylation	GLTLDQIKANQKKYG CCCHHHHHHCCHHHC	35.33	21791702
237	Phosphorylation	TAIGKIRTEMSETEE HHHHHHHHCCCCCHH	39.24	19429919
240	Phosphorylation	GKIRTEMSETEEIKT HHHHHCCCCCHHCCC	34.82	19429919
242	Phosphorylation	IRTEMSETEEIKTPL HHHCCCCCHHCCCHH	31.45	19429919
662	Phosphorylation	GREFDDLSPTEQKAA CCCCCCCCHHHHHHH	36.45	27794539
664	Phosphorylation	EFDDLSPTEQKAAVA CCCCCCHHHHHHHHH	47.90	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATC1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATC1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATC1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACT4_DROME	Act79B	physical	14605208
ATPA_DROME	blw	physical	22036573
ACADM_DROME	CG12262	physical	22036573
OST48_DROME	Ost48	physical	22036573
SURF4_DROME	Surf4	physical	22036573
ARF1_DROME	Arf79F	physical	22036573
TCPG_DROME	Cctgamma	physical	22036573
ERD2_DROME	KdelR	physical	22036573
2AAA_DROME	Pp2A-29B	physical	22036573
FAXC_DROME	fax	physical	22036573
ATPG_DROME	ATPsyn-gamma	physical	22036573
IDH3A_DROME	l(1)G0156	physical	22036573
RAB6_DROME	Rab6	physical	22036573
ATPB_DROME	ATPsyn-beta	physical	22036573
DX39B_DROME	Hel25E	physical	22036573
KRH2_DROME	Kr-h2	physical	22036573
ARL8_DROME	Gie	physical	22036573
CCD1P_DROME	Cyp12d1-p	physical	22036573
MYSA_DROME	Mhc	physical	22036573
NFS1_DROME	CG12264	physical	22036573
CATL_DROME	Cp1	physical	22036573
CDKAL_DROME	CG6550	physical	22036573
VATA2_DROME	Vha68-2	physical	22036573
COX2_DROME	COX2	physical	22036573
RAS3_DROME	R	physical	22036573
QCR9_DROME	ox	physical	22036573
JAGN_DROME	jagn	physical	22036573
BSCL2_DROME	Seipin	genetic	24807223
RYR_DROME	RyR	genetic	24098595
RS10B_DROME	RpS10b	physical	22036573

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATC1_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240, AND MASSSPECTROMETRY.	18327897 [Abstract]