VATA2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATA2_DROME
• UniProt AC: Q27331
• Protein Name: V-type proton ATPase catalytic subunit A isoform 2
• Gene Name: Vha68-2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 614
• Protein Description: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
• Protein Sequence: MSNLKRFDDEERESKYGRVFAVSGPVVTAEAMSGSAMYELVRVGYYELVGEIIRLEGDMATIQVYEETSGVTVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLKDINELTESIYIPKGVNVPSLSRVASWEFNPLNVKVGSHITGGDLYGLVHENTLVKHKMIVNPRAKGTVRYIAPSGNYKVDDVVLETEFDGEITKHTMLQVWPVRQPRPVTEKLPANHPLLTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQALSKYSNSDVIIYVGCGERGNEMSEVLRDFPELSVEIDGVTESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSKYMRALDDFYDKNFPEFVPLRTKVKEILQEEEDLSEIVQLVGKASLAETDKITLEVAKLLKDDFLQQNSYSSYDRFCPFYKTVGMLRNIIDFYDMARHSVESTAQSENKITWNVIREAMGNIMYQLSSMKFKDPVKDGEAKIKADFEQLHEDLQQAFRNLED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
126	Phosphorylation	GVNVPSLSRVASWEF CCCCCCHHHCEEEEC	29.10	21082442
130	Phosphorylation	PSLSRVASWEFNPLN CCHHHCEEEECCCCC	25.04	19429919
142	Phosphorylation	PLNVKVGSHITGGDL CCCEEECCEECCCCC	18.07	19429919
145	Phosphorylation	VKVGSHITGGDLYGL EEECCEECCCCCHHH	29.68	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATA2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATA2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATA2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VATD1_DROME	Vha36-1	physical	22036573
VATC_DROME	Vha44	physical	22036573
ACADM_DROME	CG12262	physical	22036573
VATH_DROME	VhaSFD	physical	22036573
COQ6_DROME	CG7277	physical	22036573
VATA1_DROME	Vha68-1	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142, AND MASSSPECTROMETRY.
PubMed: 18327897