dbPTM

VATD1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VATD1_DROME
UniProt AC	Q9V7D2
Protein Name	V-type proton ATPase subunit D 1
Gene Name	Vha36-1
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	246
Subcellular Localization
Protein Description	Subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity)..
Protein Sequence	MSGKDRLPIFPSRGAQMLMKARLAGAQKGHGLLKKKADALQMRFRLILGKIIETKTLMGDVMKEAAFSLAEAKFTSGDINQVVLQNVTKAQIKIRTKKDNVAGVTLPVFESYQDGSDTYELAGLARGGQQLAKLKKNYQSAVKLLVELASLQTSFVTLDEVIKITNRRVNAIEHVIIPRIDRTLAYIISELDELEREEFYRLKKIQDKKREARIKADAKKAELLQQGIDVRQQANILDEGDDDVLF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Ubiquitination	ARLAGAQKGHGLLKK HHHHCCHHCCCHHHH	52.95	31113955
50	Acetylation	RFRLILGKIIETKTL HHHHHHHHHHHHCHH	36.75	19608861
54	Phosphorylation	ILGKIIETKTLMGDV HHHHHHHHCHHHHHH	20.94	27794539
56	Phosphorylation	GKIIETKTLMGDVMK HHHHHHCHHHHHHHH	29.42	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VATD1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VATD1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VATD1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U184_DROME	CG14818	physical	22036573
VATH_DROME	VhaSFD	physical	22036573
KLD10_DROME	slim	physical	25242320

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VATD1_DROME

Related Literatures of Post-Translational Modification