| UniProt ID | BSCL2_DROME | |
|---|---|---|
| UniProt AC | Q9V3X4 | |
| Protein Name | Seipin {ECO:0000303|PubMed:21533227} | |
| Gene Name | Seipin {ECO:0000312|FlyBase:FBgn0040336} | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 370 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis.. | |
| Protein Sequence | MNILLRLIVFALDPLGLGRRFLIRPAVNLGWNVYDRVRSKADEKVGTVRELVLRLGLIAFAVVLIIWLAVFMYAAFYYVYMPAISHTRPVHMQFKTCLETSTPCTFPHAHVSLTKKQQLLMVGQAYKVIVNIDMPESPQNLELGMFMVCAEMRDYDSMLRGHSCRSAMMRYRSPLIRMISTWVLSPLYVLGWKEEFQQVPVEIFSRYLEERQHPITDVYVEIQSQKIQFYTVTLHIVADFTGLRYIMFNWPVLSAIVAISTNLFFILVVFLLSWYHWSDAKWLHSVQIKYARLTKSLEPGVIHSKASSLRDDDDDLVAYSDKSDIADVGGDTLSDVDADDLVLVKKSRSGKRESPDALRKRPTKKTTADH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 320 | Phosphorylation | DDDLVAYSDKSDIAD CCCEEEECCHHHHCC | 19429919 | ||
| 332 | Phosphorylation | IADVGGDTLSDVDAD HCCCCCCCHHHCCHH | 19429919 | ||
| 334 | Phosphorylation | DVGGDTLSDVDADDL CCCCCCHHHCCHHHE | 19429919 | ||
| 354 | Phosphorylation | SRSGKRESPDALRKR CCCCCCCCHHHHHCC | 19429919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BSCL2_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BSCL2_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BSCL2_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CDSA_DROME | CdsA | genetic | 21533227 | |
| RYR_DROME | RyR | genetic | 24807223 | |
| ATC1_DROME | Ca-P60A | genetic | 24807223 | |
| BSCL2_DROME | Seipin | physical | 24807223 | |
| LSP1A_DROME | Lsp1alpha | physical | 24807223 | |
| LSP1B_DROME | Lsp1beta | physical | 24807223 | |
| LSP1G_DROME | Lsp1gamma | physical | 24807223 | |
| USE1_DROME | Use1 | physical | 24807223 | |
| APLP_DROME | Rfabg | physical | 24807223 | |
| ATC1_DROME | Ca-P60A | physical | 24807223 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
