APLP_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APLP_DROME
• UniProt AC: Q9V496
• Protein Name: Apolipophorins {ECO:0000303|PubMed:15062105}
• Gene Name: apolpp {ECO:0000312|FlyBase:FBgn0087002}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 3351
• Subcellular Localization: Secreted. Secreted in hemolymph.
• Protein Description: Constitutes the major component of lipophorin, which mediates transport for various types of lipids in hemolymph. Acts by forming lipoprotein particles that bind lipoproteins and lipids. Also involved in the transport of hydrophobic ligands like juvenile hormones, pheromone hydrocarbons and carotenoids. Required for morphogens wingless (wg) and hedgehog (hh) function, probably by acting as vehicles for the movement of wg and hh, explaining how covalently lipidated wg and hh can spread over long distances. May also be involved in transport and/or metabolism of heme..
• Protein Sequence: MARMKYNIALIGILASVLLTIAVNAENACNLGCPKSDNGLLKYIPGNYYDYSFDSILTIGASSDVPNDSDDTSLKVSGSAKIFAKGNCGYTLQLSSVKVTNTKESVEKKILNSIQKPVQFTLVSGILEPQICSDSSDLDYSLNIKRAVVSLLQSGIEAEHEVDVFGMCPTHTSTSKVGNANIITKARNLNSCSHREQINSGLVSGKVNEKAGITSSLLLQANYIKESRIVNHLIENVQLTETYKFIGNTKRNSDISAKVVTILKLKNPSGTKANSPGTGSTVRSLIFQRPETYTSKNINALKTILSDLVDSTGDYVKKETAKKFVEFIRLLRQSDSETLLELAAFPHPNKVLARKVYLDGLFRTSTAESARVILKQLSKFDEKEKLLAILSLNIVKSVDKETLNQAASQLLPNAPKELYIAVGNLVAKYCLKNYCQGPEIDAISKKFSDGLKHCKPNTKREEERIVYILKGLGNAKSLSGNTVAALSECASTGRSNRIRVAALHAFSKVKCEETLQSKSLELLKNRNEDSELRIEAYLSAISCPNAEVANQISEIVNSETVNQVGGFISSNLKAIRDSTDVSRDQQKYHLANIRVTKTFPVDYRRYSFNNEVSYKLESLGVGASTDYQIIYSQHGFLPRSSRINVTTEFFGTNYNVFEASVRQENVEDVLEYYLGPKGLVNKDFDEIVKLIEVGNNGVAAGGRARRSIVDDVSKISKKYKMYGVKNVQDLNLDVSLKLFGSELAFLSLGDNIPSSLDDIINYFSTSFEKAKQELSSFEKQFSSHHLFLDTDLAYPTSIGVPLELVAQGFAATKVDLAVSLDINAILEQNWQKAKYRLKFVPSVDINANVQIGFNAQVLSTGLRVVSSAHSATGSDITVAVISDGEGFNVDLELPREKLELINFNVDTELYVAEQDKQKAIALKGNKKNKNSQPSEICFNQLELVGLNICIKSSTSLSEVQAGNGNVAERGLSVSEKFHLSRPFNFAVYLTTERKFTFKGIHTQEAFSQKWKLDYSTPGSKVSHDTTVVYELGNKPKTFSRLSFDNSQCHFAVEGGINNDKNELVVYGQYEQDKEIKKSKIGFSKNGNEYKPLIEIQDNNGISNSINGYHADGKIVVKKNSNNIERYNFENFQVSNSNNAHVAVNGWSDVGTNSLTSELRISLDHQTFLIKENLKLENGLYEAGFFINDEHSPENIYGSSIHLTIADQSYALKTNGKAAAWSIGSDGSFNFQKLADSNSARAGSLVENVEIQYKNKQVGGIKIMSNFDVNKMDVDVEISREQKIGSIIVKYESNQRHAQDYSLEASAKINKHSIDVISKCDFNGNVYVVDNSLVTSWGTLLSAKGEIGQRYSAQDININIQGNVQISGKDKVTQWILKVIGTPDKTNSDFRISRDTSELIKLTSESQHPQDKISFAKLNLIVKNQLTAKGEFRVAKNGKGDFTASIDTLKTEPKHKLEIESKFHIQSPKYDIDASLTLDGKRKVHLKSENTIEKLKFSTKNIGEANDKIIAFEANGSLKGELRGNGEIQGTFIFNAPDGRVIDGSINRKISTNAKSGLSQGNIDAQLSDTPFGSNKKRSISLIGKLDRLNTKTKEFSANSNLVYTAFNGEKSEISYQIKQQPNGDAKNIDFSLKAYGNPLPQPFEIAFALGDYSAQHAVVSITSKYGEIFSVSANGNYNNNQALEYGLQANIEIPKSTLKSLEINSHGKVLKSLIGNENAAYNVEFFLDSKTSLGQYARVNTVWNGTANDGSYDFEAQTNNMESPLKFNGKYHRKQTGNIKDGDLTGKQTYVLNAQYGAQYVKMDASLGYGAEKVDIAYVIDSSFDSVKDIKVNIRTFKPLDDSTYVVTALFKQTDKSYGLDTTFYHSAHKKGVDIRLDLLKEKPIIISSIAELLGDRKGKVLFEILNLADLDIKINSEASYVSIDEFYIIVNWSSKKLKLDGYELEARAQSKNIKIQLKNENGIIFSGTATYALKKELNKTIIDGQGKVQYQGKALSGNFKLTRQHFDFGTDREVGFSYTFMGNLGSKNGLGTLKITNKEFNTKFSVCEEKRQCTNLIVQSIVSIDEQKLDAVEHTTLIIVDLRDFGYPYEFELKSQNTRQGLKYQYHLDSFIITGNNFKYQFTANVQPTSSTIKLALPKRQILFETTQKIPADGSLFGRYEQTASFFIDKLQKPDDVARFSAIVDVTGTERVAFNANGKLKFEHPTIRPLSISGQLNGDVNQQIASAEVIFDIFRLPEQKVVGNSELRNSRSQNGFNIAYITTVKSAGLQFQYQINSNAAVDIEAHEYNIGLELNNGEIDVKAISFLNKEKFEISLSESNKHIIYIVGDFSKQNHYAKLNTKVQILDKNPIEITSEVQPNSAKIILKRQDFIDGTAEVKLGKEFKVDVIGSGKQLFNGRVALDATNFLQTNYFINEDHLNGFWHIVESEINKDSEYISENIKERLKKSRQVTDKIVKLAKEAGPDFSKLQGKLLDYKNDIVQELEADQSIAPIIDGIRTLFKKIAGIVDDINKAISEILEKAQKSIVDIYDKLQALWKDSLLKAWEDFIITVQKLISTLKTEFIKICTQSFKDLLSALEKYGPALKNYGKAIGEIVKPINDAAQEVIKIVVNAAEGVTHEFKQYVASLPSFESIRNEFNDKVKVLKLFEKATELTNSLFDQINILPQTPETSEFLQKLHDYLIAKLKQEHIDNEKYIEELGQLLIKAVRSIWVSIRSTYPGSSDHVIDFQSWIGSLTHSFDSLAVLPSILSFRSSILNCLLNENWDVVFNKKLLYSWIFFNDFELRGHVVDGKHIFTFDGLNFAYPGNCKYILAQDSVDNNFTIIGQLTNGKLKSITLIDREGSYFEVADNLALKLNGNLVEYPQHLSGLHAWRRFYTIHLYSEYGVGIVCTSDLKVCHININGFYTSKTRGLLGNGNAEPYDDFLLIDGTLAENSAALGNDYGVGKCTAIEFDNNQFKSSKRQEMCSELFGIESTLAFNFITLDSRPYRKACDIALAKVAEKEKEATACTFALAYGSAVKQINKWVLLPPRCIKCAGPAGQHDFGDEFTVKLPNNKVDVVFVVDINVTPGVLSNLIAPAINDIRESLRSRGFSDVQVGVIVFEETKRYPALLTSDGGKINYKGNVADVKLAGIKSFCDNCVEQIITEKRILDIYNSLKEIVKGIAPQADEKAFQLALDYPFRAGAAKSIIGVRSDSLEYKNWWKFVRAQLTGSITKFDGALIHLIAPVKGLSLEGVLSEKLIGFNSRLVATVDGKDSKKRTKLQFDNDMGIDFVLNNGGWVFATQNFEKLKASDQKKMLNQITSSLADTLFKTEIVSDCRCLPIHGLHGQHKCVIKSSTFVANKKAKSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	N-linked_Glycosylation	GASSDVPNDSDDTSL CCCCCCCCCCCCCCE	62.36	-
644	N-linked_Glycosylation	LPRSSRINVTTEFFG CCCCCCEEEEEEECC	24.79	-
707	Phosphorylation	AGGRARRSIVDDVSK CCHHHHHCHHCCHHH	22.78	22817900
713	Phosphorylation	RSIVDDVSKISKKYK HCHHCCHHHHHHHHC	31.13	27794539
1236	Phosphorylation	NFQKLADSNSARAGS CHHHHCCCCCCCCCC	27.38	27794539
1444	Phosphorylation	GKGDFTASIDTLKTE CCCCEEEEEECCCCC	20.24	19429919
1514	N-linked_Glycosylation	KIIAFEANGSLKGEL EEEEEEECCCCCEEE	33.13	-
1744	N-linked_Glycosylation	ARVNTVWNGTANDGS EEEEEEECCCCCCCC	33.33	-
1932	N-linked_Glycosylation	DEFYIIVNWSSKKLK CEEEEEEECCCCCEE	23.62	-
1979	N-linked_Glycosylation	YALKKELNKTIIDGQ HHHHHHHCCEEECCC	40.28	-
2822	N-linked_Glycosylation	AQDSVDNNFTIIGQL EECCCCCCEEEEEEE	30.86	17893096

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APLP_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APLP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APLP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATPA_DROME	blw	physical	14605208
HSP6A_DROME	Hsp67Ba	physical	14605208
WNTG_DROME	wg	physical	15875013
HH_DROME	hh	physical	15875013

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster.";
Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.;
Glycobiology 17:1388-1403(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2822, AND MASSSPECTROMETRY.
PubMed: 17893096