dbPTM

HH_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HH_DROME
UniProt AC	Q02936
Protein Name	Protein hedgehog
Gene Name	hh
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	471
Subcellular Localization	Nucleus . Cytoplasm . Nuclear up to embryonic stage 10 and then at stage 11 shifts to the cytoplasm (PubMed:1280560). Also secreted in either cleaved or uncleaved form to mediate signaling to other cells (PubMed:1280560). Protein hedgehog N-product:
Protein Description	Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection. [PubMed: 25639794 During photoreceptor differentiation, it up-regulates transcription of Ubr3, which in turn promotes the hh-signaling pathway by mediating the ubiquitination and degradation of cos]
Protein Sequence	MDNHSSVPWASAASVTCLSLDAKCHSSSSSSSSKSAASSISAIPQEETQTMRHIAHTQRCLSRLTSLVALLLIVLPMVFSPAHSCGPGRGLGRHRARNLYPLVLKQTIPNLSEYTNSASGPLEGVIRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTESWDEDYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHVHGCFTPESTALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHTDGGAVLTVTPAHLVSVWQPESQKLTFVFADRIEEKNQVLVRDVETGELRPQRVVKVGSVRSKGVVAPLTREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWLPAKEQLHSSPKVVSSAQQQNGIHWYANALYKVKDYVLPQSWRHD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
85	N-palmitoylation	VFSPAHSCGPGRGLG HHCCCHHCCCCCCCC	5.68	11486055
257	Cholesterylation	SISSHVHGCFTPEST CCCCCCCCCCCHHHH	13.72	28344083
257	Cholesterol ester	SISSHVHGCFTPEST CCCCCCCCCCCHHHH	13.72	11486055

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HH_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HH_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HH_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AST4_DROME	sc	genetic	14704182
TRR_DROME	trr	genetic	14603321
OMB_DROME	bi	genetic	9367427
FUSED_DROME	fu	genetic	9858670
FUSED_DROME	fu	genetic	10983993
DECA_DROME	dpp	genetic	16236766
WNT4_DROME	Wnt4	genetic	11180811
WNTG_DROME	wg	genetic	11546742
KAPC_DROME	Pka-C1	genetic	7854454
KAPC_DROME	Pka-C1	genetic	10769240
AMOS_DROME	amos	genetic	8252627
COS_DROME	cos	genetic	14636583
PTC_DROME	ptc	genetic	7958947
PTC_DROME	ptc	genetic	8846898
PTC_DROME	ptc	genetic	10769240
PTC_DROME	ptc	genetic	14704176
SCA_DROME	sca	genetic	12479809
PSC_DROME	Psc	genetic	10906453
MAM_DROME	mam	genetic	19474148
ASX_DROME	Asx	genetic	10906453
EXT1_DROME	ttv	genetic	17409068
EXT1_DROME	ttv	genetic	12586063
FOI_DROME	foi	genetic	15464587
DALY_DROME	dally	genetic	9374407
BRM_DROME	brm	genetic	7867491
BRM_DROME	brm	genetic	7916308
TENM_DROME	Ten-m	genetic	9142491
DOT1L_DROME	gpp	genetic	15371351
HMDH_DROME	Hmgcr	genetic	16256738
CI_DROME	ci	genetic	10409506
CI_DROME	ci	genetic	11076770
PHO_DROME	pho	genetic	10906453
DISP_DROME	disp	genetic	16256738
DISP_DROME	disp	genetic	12586063
DISP_DROME	disp	genetic	26575288
COLL_DROME	kn	genetic	10375526
PP2A_DROME	mts	genetic	18245841
GPRK2_DROME	Gprk2	genetic	17483466
NIPB_DROME	Nipped-B	genetic	18713858
HRS_DROME	Hrs	physical	26490120
IHOG_DROME	ihog	physical	20048000
IHOG_DROME	ihog	physical	21828006
IHOG_DROME	ihog	physical	17077139
PTC_DROME	ptc	physical	20048000
HH_DROME	hh	physical	16396912
APLP_DROME	Rfabg	physical	17609110
VPS28_DROME	Vps28	physical	26490120

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HH_DROME

Related Literatures of Post-Translational Modification

Palmitoylation
Reference	PubMed
"Skinny hedgehog, an acyltransferase required for palmitoylation andactivity of the hedgehog signal."; Chamoun Z., Mann R.K., Nellen D., von Kessler D.P., Bellotto M.,Beachy P.A., Basler K.; Science 293:2080-2084(2001). Cited for: PALMITOYLATION AT CYS-85, MUTAGENESIS OF CYS-85, AND MASSSPECTROMETRY.	11486055 [Abstract]