SCA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCA_DROME
• UniProt AC: P21520
• Protein Name: Protein scabrous
• Gene Name: sca
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 799
• Subcellular Localization: Late endosome . Colocalizes in late endosomes with Gp150.
• Protein Description: Involved in regulation of neurogenesis. May encode a lateral inhibitor of R8 differentiation. In conjunction with Gp150, promotes Notch activation in response to Delta by regulating acquisition of insensitivity to Delta in a subset of cells..
• Protein Sequence: MRDWQTFPDLQKKKVSRDHLNCPATMAGSNVLWPILLAVVLLQISVAFVSGAASGGVVLSDVNNMLRDAKVVTSEKPVVHSKQETEAPESSVELLRFVDDDEDSEDISSIERQDGRTMESKKMADQVRLLTKQLNALMLRRREDYEMLEHNLRKSLRLTTNANSVDADMRSELNQLREELAALRSSQSGNKERLTVEWLQQTISEIRKQLVDLQRTASNVAQDVQQRSSTFEDLATIRSDYQQLKLDLAAQRERQQQTEVYVQELREEMLQQEQDFQHALVKLQQRTRKDGSSASVEEESGSQEANQEQTGLETTADHKRRHCRFQSEQIHQLQLAQRNLRRQVNGLRFHHIDERVRSIEVEQHRIANANFNLSSQIASLDKLHTSMLELLEDVEGLQTKMDKSIPELRHEISKLEFANAQITSEQSLIREEGTNAARSLQAMAVSVSVLQEEREGMRKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLAETLVSELENVETQYEAIINKLPHDCSEVHTQTDGLHLIAPAGQRHPLMTHCTADGWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRDISQTHCAANYEGGWWFSHCQHANLNGRYNLGLTWFDAARNEWIAVKSSRMLVKRLPAVECQANASASGAFVSVSGSAADAAPSSGATTTTTTATAAPATVTTPKTNNSVVQFVAAGQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
372	N-linked_Glycosylation	RIANANFNLSSQIAS HHHCCCCCHHHHHHH	38.53	-
587	N-linked_Glycosylation	FDGSADFNRSWADYA CCCCCCCCHHHHHHH	37.31	-
618	N-linked_Glycosylation	LHHLTLDNCSRLQVQ EEEECCCCCCCEEHH	28.86	-
660	N-linked_Glycosylation	HIAEYSGNASDALNY EEEEECCCHHHHCCC	30.26	-
744	N-linked_Glycosylation	PAVECQANASASGAF CCEEEECCCCCCCCE	14.46	-
787	N-linked_Glycosylation	TVTTPKTNNSVVQFV EEECCCCCCCEEEEE	44.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOTCH_DROME	N	genetic	10959842
MAD_DROME	Mad	genetic	8681796
DL_DROME	Dl	genetic	8647397
HH_DROME	hh	genetic	12479809

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.