dbPTM

DL_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DL_DROME
UniProt AC	P10041
Protein Name	Neurogenic locus protein delta
Gene Name	Dl
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	833
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Acts as a ligand for Notch (N) receptor. Essential for proper differentiation of ectoderm. Dl is required for the correct separation of neural and epidermal cell lineages. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction..
Protein Sequence	MHWIKCLLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVEAWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCEHGHCDKPNQCVCQLGWKGALCNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPCHQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSGKCICPAGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTFDAHQYGATTQARADGLTNAQVVLIAVFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEARKQNEQNAVATMHHNGSGVGVALASASLGGKTGSNSGLTFDGGNPNIIKNTWDKSVNNICASAAAAAAAAAAADECLMYGGYVASVADNNNANSDFCVAPLQRAKSQKQLNTDPTLMHRGSPAGSSAKGASGGGPGAAEGKRISVLGEGSYCSQRWPSLAAAGVAGACSSQLMAAASVAGSGAGTAQQQRSVVCGTPHM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	N-linked_Glycosylation	ILGENSVNLTDAQRF CCCCCCCCCCCHHHH	36.72	-
137	N-linked_Glycosylation	VEAWHDTNNSGNART EEEEECCCCCCCHHH	46.88	-
167	N-linked_Glycosylation	VSSEWKTNKSESQYT HCCHHHCCCCHHHCE	41.97	-
645	Phosphorylation	NEQNAVATMHHNGSG HHHCCEEEEECCCCH	15.50	22817900
666	Phosphorylation	SASLGGKTGSNSGLT EEECCCCCCCCCCCE	49.47	3149249
778	Phosphorylation	AAEGKRISVLGEGSY CCCCCEEEEECCCCC	18.47	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	mib1	Q9VUX2	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	neur	P29503	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL28_DROME	RpL28	physical	15710747
CP190_DROME	Cp190	physical	15710747
EF1A1_DROME	Ef1alpha48D	physical	15710747
EVE_DROME	eve	physical	15710747
IMB_DROME	Fs(2)Ket	physical	15710747
RS6_DROME	RpS6	physical	15710747
STAU_DROME	stau	physical	15710747
NOTCH_DROME	N	genetic	8600026
NOTCH_DROME	N	genetic	9778511
NOTCH_DROME	N	genetic	10683181
NOTCH_DROME	N	genetic	10862754
NOTCH_DROME	N	genetic	11429287
JAK_DROME	hop	genetic	16039641
SBNO_DROME	sno	genetic	8287794
RCOR_DROME	CoRest	genetic	22331351
HERC2_DROME	HERC2	genetic	26355680
SMO_DROME	smo	genetic	23667323
EBI_DROME	ebi	genetic	12230979
STAR_DROME	S	genetic	17246581
SUDX_DROME	Su(dx)	genetic	10353900
SUDX_DROME	Su(dx)	genetic	9832525
TBG1_DROME	gammaTub23C	genetic	16415372
IHOG_DROME	ihog	genetic	23667323
BIB_DROME	bib	genetic	9367444
RL9_DROME	RpL9	genetic	8676882
SUH_DROME	Su(H)	genetic	7954795
SUH_DROME	Su(H)	genetic	9778511
HR38_DROME	Hr38	genetic	19448274
TSH_DROME	tsh	genetic	15110046
EGFR_DROME	Egfr	genetic	1980740
SRF_DROME	bs	genetic	9550715
BRE1_DROME	Bre1	genetic	15691768
ARA_DROME	ara	genetic	26305360
CAUP_DROME	caup	genetic	26305360
DCTN1_DROME	Gl	genetic	18653542
BRM_DROME	brm	genetic	15944353
MIB_DROME	mib1	genetic	16093323
GIL_DROME	aos	genetic	11944933
GIL_DROME	aos	genetic	11124124
MO25_DROME	Mo25	genetic	15975907
PSN_DROME	Psn	genetic	10493744
PSN_DROME	Psn	genetic	23318643
FNG_DROME	fng	genetic	16093323
FNG_DROME	fng	genetic	9778511
DNJC5_DROME	Csp	genetic	19448274
ATO_DROME	ato	genetic	19243220
NEUR_DROME	neur	genetic	11180964
NEUR_DROME	neur	genetic	16093323
NEUR_DROME	neur	genetic	26355680
HLES_DROME	H	genetic	9778511
HLES_DROME	H	genetic	6443124
HLES_DROME	H	genetic	8756291
HH_DROME	hh	genetic	23667323
RS3_DROME	RpS3	genetic	6443124
CRB_DROME	crb	genetic	20110329
SERR_DROME	Ser	genetic	16093323
CI_DROME	ci	genetic	23667323
VATA2_DROME	Vha68-2	genetic	19448274
RUMI_DROME	rumi	genetic	18243100
NOTCH_DROME	N	physical	2185893
MIB_DROME	mib1	physical	15829515
MIB_DROME	mib1	physical	22162135
NEUR_DROME	neur	physical	22162135

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DL_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-666, AND MASSSPECTROMETRY.	18327897 [Abstract]