dbPTM

CAUP_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CAUP_DROME
UniProt AC	P54269
Protein Name	Homeobox protein caupolican
Gene Name	caup
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	693
Subcellular Localization	Nucleus .
Protein Description	Controls proneural and vein forming genes. Positive transcriptional controler of ac-sc (achaete-scute). May act as an activator that interacts with the transcriptional complex assembled on the ac and sc promoters and participates in transcription initiation..
Protein Sequence	MAAYAQFGYAGYPTANQLTTANTDSQSGHGGGSPLSGTNEASLSPSGGSTATGLTAGPLSPGAVSQSSHHAGHKGLSTSPAEDVVGGDVPVGLSSAAQDLPSRGSCCENGRPIITDPVSGQTVCSCQYDPARLAIGGYSRMALPSGGVGVGVYGGPYPSNEQNPYPSIGVDNSAFYAPLSNPYGIKDTSPSTEMSAWTSASLQSTTGYYSYDPTLAAYGYGPNYDLAARRKNATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNKTEDDDDGMMSDDEKEKDAGDGGKLSTEAFDPGNQLIKSELGKAEKEVDSSGDQKLDLDREPHNLVAMRGLAPYATPPGAHPMHAAYSSYAQSHNTHTHPHPQQMQHHQQQQQQQQNQQQLQHHQMDQPYYHPGGYGQEESGEFAAQKNPLSRDCGIPVPASKPKIWSVADTAACKTPPPTAAYLGQNFYPPSSADQQLPHQPLQQHQQQQLQQLQQQQQHHHHPHHHHPHHSMELGSPLSMMSSYAGGSPYSRIPTAYTEAMGMHLPSSSSSSSSTGKLPPTHIHPAPQRVGFPEIQPDTPPQTPPTMKLNSSGGSSSSSGSSHSSSMHSVTPVTVASMVNILYSNTDSGYGHGHSHGHGHGHGHGLGHGHGLGHGHGHMGVTSNAYLTEGGRSGS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
298	Phosphorylation	TWEPKNKTEDDDDGM CCCCCCCCCCCCCCC	54.78	22817900
307	Phosphorylation	DDDDGMMSDDEKEKD CCCCCCCCHHHHHHC	32.77	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CAUP_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CAUP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CAUP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DOD_DROME	dod	physical	14605208
NOTCH_DROME	N	genetic	9834035
CCNE_DROME	CycE	genetic	26305360
FBXW7_DROME	ago	genetic	26305360
DIAP1_DROME	th	genetic	26305360
CAUP_DROME	caup	physical	23847101
SF3B5_DROME	CG11985	physical	25242320

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CAUP_DROME

Related Literatures of Post-Translational Modification