FBXW7_DROME - dbPTM
FBXW7_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FBXW7_DROME
UniProt AC Q9VZF4
Protein Name F-box/WD repeat-containing protein 7
Gene Name ago {ECO:0000312|EMBL:AAL28848.1}
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1326
Subcellular Localization Nucleus.
Protein Description Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins (By similarity). In the wing and eye, negatively regulates cell growth and proliferation by mediating the degradation of Myc and cyclin E, respectively. [PubMed: 11565033]
Protein Sequence MERGCPAASSESVTSAGERTQSAVTSSTSTWVKSQASTSRKTEASEESGLGAVDAEVGAGREAFVSMSTLREDVEDVCVSSNSQHGFAVVLDDESSTFEISSSNSLPTSAGAASTVGVVAVDDSSSTDTLNGGHPDLGHPASSEHSRQGFFNEDNEDPPVVCLINDDDDDEEPEPEEDDEEELIEDEDEDAVDIVTGAISCPNTSQLALADGTIMAADGSKIFLETPVVEEAQPHPGQVVTTGSQSELTGKPKRLSDEFLLGEEDQAENLALGRCIKSEPVNPVDDNPSEGDDGATCFSLHDRLMSVRLKQMSLTANTVSNPSPAASANAAAPEEASTSNSSSTSSSALSRADIESMDLIERRDFETEQRLTGGIILRTSSMVSQNKLNLSLIKSMAGGSKAANGSGTANSDDWPSSSNGRTVSSDSKYTYKDLSTTPTSSRKYTNSRLSKSTAKLNLGSSLGASSCSQHRSGSSSTSKSMESSTSCTGAARTDVYTNTNSNDYPSLAPTTSGSSTSGGSCQQDQEENVSASVSYSSVGSQTSQESGCSRTTAINPTAACSTGSACLGDSQASTSASTSSGAGASNRCQYATTSTTKAARQVNASAQTQERFLTRSNPPAASGAGSVGANPTASVRQRRNGSSDVVHLEVVVEEGAGGGDGGVVEPGDFSAEEPWANCDEENNCSDLEEICTCQNGNGSSYGGSNASLSETFDMDAMDPDEPISLSLSSASAGFTEYSLTNPSSLMSHQRKRKFNEGRLLDGGDYSVTISSSGEVGGPGSGVSDNCRKRIAYDFASTPRSSQHLGPTAVLSVTPSSHLTSSTPGSALGRRTPRSVPSRDNPPPELQHWLAQFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKCRKAQILAEPRSDRPKRGRDGNMPPIASPWKAAYMRQHIIEMNWRSRPVRKPKVLKGHDDHVITCLQFSGNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLHGSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTNRVYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQNILVSGNADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWDVKTGDFIRNLVALDSGGSGGVVWRIRANDTKLICAVGSRNGTEETKLMVLDFDVEGACVKCS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
256PhosphorylationTGKPKRLSDEFLLGE
CCCCCCCCCCCCCCC		38.8419429919
381PhosphorylationGIILRTSSMVSQNKL
CEEEECCCCCCCCCC		23.6921082442
813PhosphorylationPTAVLSVTPSSHLTS
CEEEEEECCCCCCCC		17.6822817900
825PhosphorylationLTSSTPGSALGRRTP
CCCCCCCCCCCCCCC		22.8618327897
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FBXW7_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FBXW7_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FBXW7_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RS3_DROMERpS3physical
14605208
CCNE_DROMECycEgenetic
11565033
DYL1_DROMEctpphysical
15710747
UBIQP_DROMEUbi-p63Ephysical
15710747
DECA_DROMEdppphysical
15710747
RLA0_DROMERpLP0physical
15710747
ATNA_DROMEAtpalphaphysical
15710747
H2AV_DROMEHis2Avphysical
15710747
HSP7D_DROMEHsc70-4physical
15710747
HSP71_DROMEHsp70Abphysical
15710747
HSP70_DROMEHsp70Abphysical
15710747
METK_DROMESam-Sphysical
15710747
ATPB1_DROMEnrv1physical
15710747
RL7A_DROMERpL7Aphysical
15710747
RS5A_DROMERpS5aphysical
15710747
SEM2A_DROMESema-2aphysical
15710747
RS2_DROMERpS2physical
15710747
WDS_DROMEwdsphysical
15710747
CCNE_DROMECycEphysical
11565033
TRH_DROMEtrhgenetic
17976568
FGFR2_DROMEbtlgenetic
17976568
SIMA_DROMEsimagenetic
23459416
NDKA_DROMEawdgenetic
17976568
VHL_DROMEVhlgenetic
23459416
TRH_DROMEtrhphysical
17976568
SIMA_DROMEsimaphysical
23459416
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FBXW7_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-813 AND SER-825, ANDMASS SPECTROMETRY.

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