FGFR2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FGFR2_DROME
• UniProt AC: Q09147
• Protein Name: Fibroblast growth factor receptor homolog 2
• Gene Name: btl
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1052
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: May be required for patterning of muscle precursor cells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation. Essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues..
• Protein Sequence: MAKVPITLVMIIAIVSAAADLGCDYGHHRCYIDVTVENSPRQRHLLSDMDITLQCVRPMAKWFYEDKFQLRATLLRLERAQSGNSGNYGCLDSQNRWYNISLVVGHKEPVGNDIASFVKLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPDAKGVNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELGVYVQKNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLETPPSSGDEDDGSDTETFRETSPLRYQYTYKFN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	N-linked_Glycosylation	DSQNRWYNISLVVGH CCCCCEEEEEEEEEC	15.48	-
137	N-linked_Glycosylation	DLFFQPLNESRSLKL CCCCCCCCCCCCCHH	52.46	-
175	N-linked_Glycosylation	DPDAKGVNISWLHND CCCCCCCCEEEECCC	31.11	-
181	N-linked_Glycosylation	VNISWLHNDTQILGG CCEEEECCCCCCCCC	52.43	-
249	N-linked_Glycosylation	LKPGYPRNTSIALGD CCCCCCCCCCEECCC	33.40	-
257	N-linked_Glycosylation	TSIALGDNVSIECLL CCEECCCCEEEEEEE	27.86	-
423	N-linked_Glycosylation	CPVYGKANITWTKDK CEECCEECCEECCCC	35.39	-
444	N-linked_Glycosylation	LGVYVQKNWTLRFVE CEEEEECCEEEEEEE	21.63	-
494	N-linked_Glycosylation	PIIVVPQNQTVKVNG CEEEECCCCEEEECC	33.16	-
500	N-linked_Glycosylation	QNQTVKVNGSLVMKC CCCEEEECCEEEEEE	28.72	-
526	N-linked_Glycosylation	WKRVVLKNASLDGLK EEEEEEECCCCCCCC	30.51	-
541	N-linked_Glycosylation	SVEIQNLNFTVTNDS EEEEEECEEEECCCE	37.78	-
546	N-linked_Glycosylation	NLNFTVTNDSVVLTL ECEEEECCCEEEEEE	34.91	-
555	N-linked_Glycosylation	SVVLTLRNVTFDQEG EEEEEEECEEECCCC	40.05	-
576	N-linked_Glycosylation	SSGLGRSNSSVYLRV ECCCCCCCCEEEEEE	36.62	-
895	Phosphorylation	DIQDTEYYRKNTNGR CCCCCCHHCCCCCCC	14.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FGFR2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FGFR2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FGFR2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DSH_DROME	dsh	genetic	17032066
CDC42_DROME	Cdc42	genetic	22384378
GCH1_DROME	Pu	genetic	17585895
RAC1_DROME	Rac1	genetic	17032066
SMN_DROME	Smn	genetic	21300852
KNRL_DROME	knrl	genetic	15848387
KNIR_DROME	kni	genetic	15848387
RAS1_DROME	Ras85D	genetic	9809073
NDKA_DROME	awd	genetic	14630942

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.