SMN_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMN_DROME
• UniProt AC: Q9VV74
• Protein Name: Survival motor neuron protein {ECO:0000312|EMBL:AAG17893.1}
• Gene Name: Smn
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 226
• Subcellular Localization: Cytoplasm . Nucleus, gem . Cytoplasm, myofibril, sarcomere, I band . Cytoplasm, myofibril, sarcomere, Z line . Component of U bodies. High expression detected in the cytoplasm of female germline stem cells and cystoblast which persists up to stage 10
• Protein Description: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm, is required for pre-mRNA splicing in the nucleus and acts as a chaperone that discriminates target and non-target RNAs of Sm proteins. Required for normal expression of spliceosomal snRNAs and for U12 intron splicing. Required in cholinergic neurons, but not in motor neurons, to ensure correct splicing and proper levels of stas mRNA and normal neurotransmitter release by motor neurons. [PubMed: 23063130 and 23063131). However]
• Protein Sequence: MSDETNAAVWDDSLLVKTYDESVGLAREALARRLADSTNKREEENAAAAEEEAGEISATGGATSPEPVSFKVGDYARATYVDGVDYEGAVVSINEEKGTCVLRYLGYENEQEVLLVDLLPSWGKRVRREQFLIAKKDEDEQLSRPKASAGSHSKTPKSSRRSRISGGLVMPPMPPVPPMIVGQGDGAEQDFVAMLTAWYMSGYYTGLYQGKKEASTTSGKKKTPKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	EEEAGEISATGGATS HHHHCCCCCCCCCCC		22817900
63	Phosphorylation	ISATGGATSPEPVSF CCCCCCCCCCCCCEE		22817900
64	Phosphorylation	SATGGATSPEPVSFK CCCCCCCCCCCCEEE		28490779
151	Phosphorylation	RPKASAGSHSKTPKS CCCCCCCCCCCCCCC		30478224
153	Phosphorylation	KASAGSHSKTPKSSR CCCCCCCCCCCCCCC		30478224
155	Phosphorylation	SAGSHSKTPKSSRRS CCCCCCCCCCCCCCC		30478224

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMN_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMN_DROME	Smn	physical	14605208
RAC2_DROME	Rac2	physical	14605208
Y2199_DROME	CG2199	physical	14605208
ACTN_DROME	Actn	physical	17353360
GEMI2_DROME	Gem2	physical	22036573
SYFB_DROME	CG5706	physical	22036573
WHITE_DROME	w	genetic	24768745
DYL1_DROME	ctp	genetic	18791638
MOEH_DROME	Moe	genetic	18791638
A37C_DROME	CG10561	genetic	18791638
EIF3M_DROME	Tango7	genetic	23757500
SPY_DROME	sty	genetic	21300852
SODC_DROME	Sod	genetic	23757500
FGFR2_DROME	btl	genetic	21300852
E75BB_DROME	Eip75B	genetic	23757500
E75BC_DROME	Eip75B	genetic	23757500
E75BA_DROME	Eip75B	genetic	23757500
FGFR1_DROME	htl	genetic	21300852
1433E_DROME	14-3-3epsilon	genetic	23757500
RUXE_DROME	SmE	physical	18984161
ICLN_DROME	icln	physical	23333303
SMN_DROME	Smn	physical	22813737
SMN_DROME	Smn	physical	25144193
SMN_DROME	Smn	physical	12783845
GEMI2_DROME	Gem2	physical	25144193
GEMI2_DROME	Gem2	physical	23333303
GEMI2_DROME	Gem2	physical	18984161
SMD2_DROME	SmD2	physical	18984161
SMD1_DROME	SmD1	physical	18984161

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.